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CFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation
期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:
Muendlein H.I.
;
Jetton D.
;
Connolly W.M.
;
Eidell K.P.
;
Magri Z.
;
Smirnova I.
;
Poltorak A.
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/07/28
FLICE inhibitory protein
interleukin 1beta
lipopolysaccharide
messenger RNA
succinate dehydrogenase (ubiquinone)
Casp1 protein, mouse
caspase 8
Cflar protein, mouse
cryopyrin
FLICE inhibitory protein
IL1B protein, mouse
inflammasome
interleukin 1beta
interleukin 1beta converting enzyme
lipopolysaccharide
succinate dehydrogenase (ubiquinone)
cell
enzyme activity
inhibition
maturation
protein
animal cell
animal experiment
Article
bone marrow derived macrophage
cell death
cell protection
complex formation
controlled study
cytokine release
in vitro study
inflammation
mouse
nonhuman
priority journal
protein analysis
protein degradation
protein function
protein interaction
pyroptosis
animal
gene knockdown
genetics
immunology
macrophage
macrophage activation
metabolism
physiology
Murinae
Animals
CASP8 and FADD-Like Apoptosis Regulating Protein
Caspase 1
Caspase 8
Electron Transport Complex II
Gene Knockdown Techniques
Inflammasomes
Interleukin-1beta
Lipopolysaccharides
Macrophage Activation
Macrophages
Mice
NLR Family, Pyrin Domain-Containing 3 Protein
Pyroptosis
Old carbon reservoirs were not important in the deglacial methane budget
期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:
Dyonisius M.N.
;
Petrenko V.V.
;
Smith A.M.
;
Hua Q.
;
Yang B.
;
Schmitt J.
;
Beck J.
;
Seth B.
;
Bock M.
;
Hmiel B.
;
Vimont I.
;
Menking J.A.
;
Shackleton S.A.
;
Baggenstos D.
;
Bauska T.K.
;
Rhodes R.H.
;
Sperlich P.
;
Beaudette R.
;
Harth C.
;
Kalk M.
;
Brook E.J.
;
Fischer H.
;
Severinghaus J.P.
;
Weiss R.F.
收藏
  |  
浏览/下载:117/0
  |  
提交时间:2020/07/28
carbon
carbon 14
carbon dioxide
carbon monoxide
deuterium
hydrocarbon
hydrogen
methane
nitrogen oxide
biomass burning
carbon
deglaciation
global warming
Holocene
methane
permafrost
reservoir
aerosol
air pollution
Article
atmosphere
biomass
carbon cycle
carbon footprint
deglaciation
environmental temperature
Holocene
ice core record
ice sheet
lake
landslide
moisture
permafrost
priority journal
sediment
soil
thawing
Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations
期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:
Wilmes S.
;
Hafer M.
;
Vuorio J.
;
Tucker J.A.
;
Winkelmann H.
;
Löchte S.
;
Stanly T.A.
;
Pulgar Prieto K.D.
;
Poojari C.
;
Sharma V.
;
Richter C.P.
;
Kurre R.
;
Hubbard S.R.
;
Christopher Garcia K.
;
Moraga I.
;
Vattulainen I.
;
Hitchcock I.S.
;
Piehler J.
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/28
cytokine receptor
homodimer
Janus kinase 2
ligand
oncoprotein
cancer
enzyme
enzyme activity
membrane
molecular analysis
mutation
protein
activation analysis
Article
cell membrane
computer model
controlled study
dimerization
fluorescence microscopy
gene mutation
HeLa cell line
molecular dynamics
mutant
oncogene
priority journal
protein domain
protein interaction
quantitative analysis
signal transduction
PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis
期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:
Wang Q.
;
Boshoff H.I.M.
;
Harrison J.R.
;
Ray P.C.
;
Green S.R.
;
Wyatt P.G.
;
Barry Iii C.E.
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/28
3,3 bis di(methylsulfonyl)propionamide
antiinfective agent
bacterial protein
glucose
glycerol
magnesium
phosphate
propionamide derivative
protein proline proline glutamate
protein proline proline glutamate 51
unclassified drug
amide
bacterial protein
lipid
phthiocerol dimycocerosate
propionamide
thiol derivative
cell component
chemical compound
membrane
mutation
protein
tuberculosis
antibiotic resistance
Article
bacterial cell
bacterial cell wall
bacterial growth
bacterial outer membrane
cell division
drug structure
Mycobacterium tuberculosis
nonhuman
nutrient uptake
priority journal
protein depletion
cell membrane
cell membrane permeability
chemistry
drug effect
gene deletion
genetics
metabolism
transport at the cellular level
Mycobacterium tuberculosis
Amides
Bacterial Proteins
Biological Transport
Cell Membrane
Cell Membrane Permeability
Drug Resistance, Bacterial
Gene Deletion
Glucose
Glycerol
Lipids
Mycobacterium tuberculosis
Sulfhydryl Compounds
On impact and volcanism across the Cretaceous-Paleogene boundary
期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:
Hull P.M.
;
Bornemann A.
;
Penman D.E.
;
Henehan M.J.
;
Norris R.D.
;
Wilson P.A.
;
Blum P.
;
Alegret L.
;
Batenburg S.J.
;
Bown P.R.
;
Bralower T.J.
;
Cournede C.
;
Deutsch A.
;
Donner B.
;
Friedrich O.
;
Jehle S.
;
Kim H.
;
Kroon D.
;
Lippert P.C.
;
Loroch D.
;
Moebius I.
;
Moriya K.
;
Peppe D.J.
;
Ravizza G.E.
;
Röhl U.
;
Schueth J.D.
;
Sepúlveda J.
;
Sexton P.F.
;
Sibert E.C.
;
Śliwińska K.K.
;
Summons R.E.
;
Thomas E.
;
Westerhold T.
;
Whiteside J.H.
;
Yamaguchi T.
;
Zachos J.C.
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/07/28
carbon dioxide
carbon dioxide
carbon cycle
carbon dioxide
Cretaceous-Paleogene boundary
flood basalt
global warming
mass extinction
paleotemperature
volcanism
Article
astronomy
basalt
bolide
boundary layer
carbon cycle
confusion (uncertainty)
cosmological phenomena
end Cretaceous mass extinction
environmental impact
environmental temperature
greenhouse effect
paleoenvironment
Paleogene
priority journal
sea
volcanic outgassing
volcanism
carbon cycle
Mexico
species extinction
theoretical model
volcano
Carbon Cycle
Carbon Dioxide
Extinction, Biological
Global Warming
Mexico
Models, Theoretical
Volcanic Eruptions
De novo protein design enables the precise induction of RSV-neutralizing antibodies
期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:
Sesterhenn F.
;
Yang C.
;
Bonet J.
;
Cramer J.T.
;
Wen X.
;
Wang Y.
;
Chiang C.-I.
;
Abriata L.A.
;
Kucharska I.
;
Castoro G.
;
Vollers S.S.
;
Galloux M.
;
Dheilly E.
;
Rosset S.
;
Corthésy P.
;
Georgeon S.
;
Villard M.
;
Richard C.-A.
;
Descamps D.
;
Delgado T.
;
Oricchio E.
;
Rameix-Welti M.-A.
;
Más V.
;
Ervin S.
;
Eléouët J.-F.
;
Riffault S.
;
Bates J.T.
;
Julien J.-P.
;
Li Y.
;
Jardetzky T.
;
Krey T.
;
Correia B.E.
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/28
algorithm
antibody
design
neutralization
protein
vaccine
Mus
Primates
Respiratory syncytial virus
Rice stripe virus
epitope
fusion protein
nanobody
neutralizing antibody
respiratory syncytial virus vaccine
biology
biosynthesis
chemistry
human
Human respiratory syncytial virus
immunology
procedures
protein conformation
protein engineering
protein motif
Amino Acid Motifs
Antibodies, Neutralizing
Computational Biology
Humans
Immunodominant Epitopes
Protein Conformation
Protein Engineering
Recombinant Fusion Proteins
Respiratory Syncytial Virus Vaccines
Respiratory Syncytial Virus, Human
Single-Domain Antibodies
Forest microclimate dynamics drive plant responses to warming
期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:
Zellweger F.
;
de Frenne P.
;
Lenoir J.
;
Vangansbeke P.
;
Verheyen K.
;
Bernhardt-Römermann M.
;
Baeten L.
;
Hédl R.
;
Berki I.
;
Brunet J.
;
van Calster H.
;
Chudomelová M.
;
Decocq G.
;
Dirnböck T.
;
Durak T.
;
Heinken T.
;
Jaroszewicz B.
;
Kopecký M.
;
Máliš F.
;
Macek M.
;
Malicki M.
;
Naaf T.
;
Nagel T.A.
;
Ortmann-Ajkai A.
;
Petřík P.
;
Pielech R.
;
Reczynska K.
;
Schmidt W.
;
Standovár T.
;
Swierkosz K.
;
Teleki B.
;
Vild O.
;
Wulf M.
;
Coomes D.
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/28
biodiversity
canopy architecture
climate change
community response
disequilibrium
land use change
microclimate
plant community
understory
warming
Europe
forest
greenhouse effect
microclimate
physiology
tree
Europe
Forests
Global Warming
Microclimate
Trees
Color, composition, and thermal environment of Kuiper Belt object (486958) Arrokoth
期刊论文
, 2020, 卷号: 367, 期号: 6481
作者:
Grundy W.M.
;
Bird M.K.
;
Britt D.T.
;
Cook J.C.
;
Cruikshank D.P.
;
Howett C.J.A.
;
Krijt S.
;
Linscott I.R.
;
Olkin C.B.
;
Parker A.H.
;
Protopapa S.
;
Ruaud M.
;
Umurhan O.M.
;
Young L.A.
;
Dalle Ore C.M.
;
Kavelaars J.J.
;
Keane J.T.
;
Pendleton Y.J.
;
Porter S.B.
;
Scipioni F.
;
Spencer J.R.
;
Stern S.A.
;
Verbiscer A.J.
;
Weaver H.A.
;
Binzel R.P.
;
Buie M.W.
;
Buratti B.J.
;
Cheng A.
;
Earle A.M.
;
Elliott H.A.
;
Gabasova L.
;
Gladstone G.R.
;
Hill M.E.
;
Horanyi M.
;
Jennings D.E.
;
Lunsford A.W.
;
McComas D.J.
;
McKinnon W.B.
;
McNutt R.L.
;
Jr.
;
Moore J.M.
;
Parker J.W.
;
Quirico E.
;
Reuter D.C.
;
Schenk P.M.
;
Schmitt B.
;
Showalter M.R.
;
Singer K.N.
;
Weigle G.E.
;
II
;
Zangari A.M.
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2020/07/28
brightness temperature
chemical composition
color
environmental conditions
solar system
spacecraft
486958 Arrokoth
Article
astronomy
color
environmental factor
environmental temperature
heat transfer
image quality
infrared spectroscopy
Kuiper Belt
microwave radiometry
principal component analysis
priority journal
radiometry
space flight
spectral imaging
thermal environment
Microglia monitor and protect neuronal function through specialized somatic purinergic junctions
期刊论文
, 2020, 卷号: 367, 期号: 6477
作者:
Cserép C.
;
Pósfai B.
;
Lénárt N.
;
Fekete R.
;
László Z.I.
;
Lele Z.
;
Orsolits B.
;
Molnár G.
;
Heindl S.
;
Schwarcz A.D.
;
Ujvári K.
;
Környei Z.
;
Tóth K.
;
Szabadits E.
;
Sperlágh B.
;
Baranyi M.
;
Csiba L.
;
Hortobágyi T.
;
Maglóczky Z.
;
Martinecz B.
;
Szabó G.
;
Erdélyi F.
;
Szipocs R.
;
Tamkun M.M.
;
Gesierich B.
;
Duering M.
;
Katona I.
;
Liesz A.
;
Tamás G.
;
Dénes Á.
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/07/28
calcium
purinergic P2Y12 receptor
brain
cell component
homeostasis
inhibition
protein
animal cell
Article
brain injury
controlled study
functional connectivity
human
human cell
microglia
mitochondrion
mouse
nerve cell
neuroprotection
nonhuman
perikaryon
priority journal
signal transduction
somatic microglia neuron junction
Endoplasmic reticulum contact sites regulate the dynamics of membraneless organelles
期刊论文
, 2020, 卷号: 367, 期号: 6477
作者:
Lee J.E.
;
Cathey P.I.
;
Wu H.
;
Parker R.
;
Voeltz G.K.
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/28
cell component
cell organelle
membrane
protein
Article
biogenesis
cell division
cell organelle
cell population
cell proliferation
cell structure
controlled study
cytoplasm
dimerization
endoplasmic reticulum
endoplasmic reticulum stress
endosome
fluorescence microscopy
human
human cell
membraneless organelle
mitochondrion
priority journal
ribonucleoprotein granule
RNA translation
stress granule