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| Review on Meteorological and Air Quality Factors Affecting the COVID-19 Pandemic 科技报告 , 2021 作者: [unavailable] Adobe PDF(1972Kb)  |  收藏  |  浏览/下载:27/2  |  提交时间:2021/11/24 |
| Coronavirus replication-transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit 期刊论文 Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 6 作者: Slanina H.; Madhugiri R.; Bylapudi G.; Schultheiß K.; Karl N.; Gulyaeva A.; Gorbalenya A.E.; Linne U.; Ziebuhr J. 收藏  |  浏览/下载:128/0  |  提交时间:2021/05/24 |
| Protease cleavage of RNF20 facilitates coronavirus replication via stabilization of SREBP1 期刊论文 Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 37 作者: Zhang S.; Wang J.; Cheng G. 收藏  |  浏览/下载:7/0  |  提交时间:2022/02/22 |
| Bepridil is potent against SARS-CoV-2 in vitro 期刊论文 Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 10 作者: Vatansever E.C.; Yang K.S.; Drelich A.K.; Kratch K.C.; Cho C.-C.; Kempaiah K.R.; Hsu J.C.; Mellott D.M.; Xu S.; Tseng C.-T.K.; Liu W.R. 收藏  |  浏览/下载:36/0  |  提交时间:2021/05/24 |
| Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文 , 2020, 卷号: 368, 期号: 6497 作者: Dai W.; Zhang B.; Jiang X.-M.; Su H.; Li J.; Zhao Y.; Xie X.; Jin Z.; Peng J.; Liu F.; Li C.; Li Y.; Bai F.; Wang H.; Cheng X.; Cen X.; Hu S.; Yang X.; Wang J.; Liu X.; Xiao G.; Jiang H.; Rao Z.; Zhang L.-K.; Xu Y.; Yang H.; Liu H. 收藏  |  浏览/下载:36/0  |  提交时间:2020/07/28 aldehyde antimicrobial activity drug enzyme activity infectivity inhibitor reaction kinetics viral disease Coronavirus SARS coronavirus 3C-like proteinase, Coronavirus antivirus agent cysteine proteinase viral protein animal Betacoronavirus chemical structure chemistry Chlorocebus aethiops Coronavirus infection dog drug design drug effect enzyme active site enzymology female human male mouse pandemic preclinical study protein tertiary structure Sprague Dawley rat toxicity testing Vero cell line virus pneumonia Animals Antiviral Agents Betacoronavirus Catalytic Domain Chlorocebus aethiops Coronavirus Infections Cysteine Endopeptidases Dogs Drug Design Drug Evaluation, Preclinical Female Humans Male Mice Molecular Structure Pandemics Pneumonia, Viral Protein Structure, Tertiary Rats, Sprague-Dawley Toxicity Tests Vero Cells Viral Nonstructural Proteins |
| Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved a-ketoamide inhibitors 期刊论文 , 2020, 卷号: 368, 期号: 6489 作者: Zhang L.; Lin D.; Sun X.; Curth U.; Drosten C.; Sauerhering L.; Becker S.; Rox K.; Hilgenfeld R. 收藏  |  浏览/下载:35/0  |  提交时间:2020/07/28 alanine alpha ketoamide inhibitor antivirus agent isoleucine leucine proteinase Severe acute respiratory syndrome coronavirus 2 main protease threonine unclassified drug crystal structure drug enzyme enzyme activity inhibitor reaction kinetics amino acid sequence animal cell animal experiment animal tissue antiviral activity Article catalysis catalytic efficiency controlled study crystal structure dimerization dissociation constant drug clearance drug design drug distribution drug half life drug potency drug protein binding drug solubility drug structure EC50 enzyme inhibition human human cell hydrogen bond hydrophobicity IC50 maximum concentration mean residence time metabolic stability mouse nonhuman priority journal protein structure RNA replication SARS coronavirus Severe acute respiratory syndrome coronavirus 2 viral tropism virus inhibition Coronavirus SARS coronavirus |