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Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Gao Y.;  Yan L.;  Huang Y.;  Liu F.;  Zhao Y.;  Cao L.;  Wang T.;  Sun Q.;  Ming Z.;  Zhang L.;  Ge J.;  Zheng L.;  Zhang Y.;  Wang H.;  Zhu Y.;  Zhu C.;  Hu T.;  Hua T.;  Zhang B.;  Yang X.;  Li J.;  Yang H.;  Liu Z.;  Xu W.;  Guddat L.W.;  Wang Q.;  Lou Z.;  Rao Z.
收藏  |  浏览/下载:44/0  |  提交时间:2020/07/28
comparative study  drug  electron microscopy  enzyme  enzyme activity  RNA  virus  Coronavirus  SARS coronavirus  adenosine phosphate  alanine  antivirus agent  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  beta sheet  Betacoronavirus  chemistry  cryoelectron microscopy  drug design  enzyme active site  enzymology  metabolism  molecular model  protein domain  ultrastructure  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Drug Design  Models, Molecular  Protein Conformation, beta-Strand  Protein Domains  RNA Replicase  Viral Nonstructural Proteins  
Total synthesis reveals atypical atropisomerism in a small-molecule natural product, tryptorubin A 期刊论文
, 2020, 卷号: 367, 期号: 6476
作者:  Reisberg S.H.;  Gao Y.;  Walker A.S.;  Helfrich E.J.N.;  Clardy J.;  Baran P.S.
收藏  |  浏览/下载:34/0  |  提交时间:2020/07/28
alkaloid  tryptorubin A  unclassified drug  alkaloid  connectivity  molecular analysis  peptide  alkylation  Article  bioinformatics  carbon nuclear magnetic resonance  chemical structure  chirality  cyclization  dehydrogenation  high performance liquid chromatography  hydrogen bond  hydrophobicity  isomerism  nonhuman  nuclear magnetic resonance spectroscopy  oxidation  priority journal  protein processing  proton nuclear magnetic resonance  stereochemistry  Streptomyces  synthesis  X ray crystallography