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Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Dai W.;  Zhang B.;  Jiang X.-M.;  Su H.;  Li J.;  Zhao Y.;  Xie X.;  Jin Z.;  Peng J.;  Liu F.;  Li C.;  Li Y.;  Bai F.;  Wang H.;  Cheng X.;  Cen X.;  Hu S.;  Yang X.;  Wang J.;  Liu X.;  Xiao G.;  Jiang H.;  Rao Z.;  Zhang L.-K.;  Xu Y.;  Yang H.;  Liu H.
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/28
aldehyde  antimicrobial activity  drug  enzyme activity  infectivity  inhibitor  reaction kinetics  viral disease  Coronavirus  SARS coronavirus  3C-like proteinase, Coronavirus  antivirus agent  cysteine proteinase  viral protein  animal  Betacoronavirus  chemical structure  chemistry  Chlorocebus aethiops  Coronavirus infection  dog  drug design  drug effect  enzyme active site  enzymology  female  human  male  mouse  pandemic  preclinical study  protein tertiary structure  Sprague Dawley rat  toxicity testing  Vero cell line  virus pneumonia  Animals  Antiviral Agents  Betacoronavirus  Catalytic Domain  Chlorocebus aethiops  Coronavirus Infections  Cysteine Endopeptidases  Dogs  Drug Design  Drug Evaluation, Preclinical  Female  Humans  Male  Mice  Molecular Structure  Pandemics  Pneumonia, Viral  Protein Structure, Tertiary  Rats, Sprague-Dawley  Toxicity Tests  Vero Cells  Viral Nonstructural Proteins  
Emergence of complexity in hierarchically organized chiral particles 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Jiang W.;  Qu Z.-B.;  Kumar P.;  Vecchio D.;  Wang Y.;  Ma Y.;  Bahng J.H.;  Bernardino K.;  Gomes W.R.;  Colombari F.M.;  Lozada-Blanco A.;  Veksler M.;  Marino E.;  Simon A.;  Murray C.;  Muniz S.R.;  de Moura A.F.;  Kotov N.A.
收藏  |  浏览/下载:27/0  |  提交时间:2020/07/28
biomaterial  cetrimide  cysteine  gold  nanocomposite  nanoparticle  chemical property  colloid  complexation  complexity  composite  ligand  nanoparticle  physicochemical property  symmetry  adsorption  Article  biomineralization  chemical structure  chirality  circular dichroism  coccolith  enthalpy  entropy  ionic strength  molecular weight  particle size  priority journal  spike wave  thermodynamics  zeta potential  Humulus  
Cysteine depletion induces pancreatic tumor ferroptosis in mice 期刊论文
, 2020, 卷号: 368, 期号: 6486
作者:  Badgley M.A.;  Kremer D.M.;  Carlo Maurer H.;  DelGiorno K.E.;  Lee H.-J.;  Purohit V.;  Sagalovskiy I.R.;  Ma A.;  Kapilian J.;  Firl C.E.M.;  Decker A.R.;  Sastra S.A.;  Palermo C.F.;  Andrade L.R.;  Sajjakulnukit P.;  Zhang L.;  Tolstyka Z.P.;  Hirschhorn T.;  Lamb C.;  Liu T.;  Gu W.;  Scott Seeley E.;  Stone E.;  Georgiou G.;  Manor U.;  Iuga A.;  Wahl G.M.;  Stockwell B.R.;  Lyssiotis C.A.;  Olive K.P.
收藏  |  浏览/下载:31/0  |  提交时间:2020/07/28
coenzyme A  cysteine  glutathione  amino acid  induced response  rodent  tumor  animal experiment  animal model  animal tissue  Article  cell death  cell survival  cell viability  controlled study  down regulation  ferroptosis  fragmentation reaction  human  human cell  lipid oxidation  lipophilicity  mouse  necroptosis  nonhuman  pancreas tumor  pancreatic ductal carcinoma cell line  priority journal  protein cleavage  protein expression  tumor growth  tumor microenvironment  tumor xenograft  Mus  
Rapid turnover of antimicrobial-type cysteine-rich protein genes in closely related Oryza genomes 期刊论文
MOLECULAR GENETICS AND GENOMICS, 2015, 卷号: 290, 期号: 5
作者:  Shenton, Matthew R.;  Ohyanagi, Hajime;  Wang, Zi-Xuan;  Toyoda, Atsushi;  Fujiyama, Asao;  Nagata, Toshifumi;  Feng, Qi;  Han, Bin;  Kurata, Nori
收藏  |  浏览/下载:47/0  |  提交时间:2019/11/08
CRP  Cysteine  Evolution  Gene cluster  Oryza