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Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Guthrie L.M.;  Soma S.;  Yuan S.;  Silva A.;  Zulkifli M.;  Snavely T.C.;  Greene H.F.;  Nunez E.;  Lynch B.;  de Ville C.;  Shanbhag V.;  Lopez F.R.;  Acharya A.;  Petris M.J.;  Kim B.-E.;  Gohil V.M.;  Sacchettini J.C.
收藏  |  浏览/下载:28/0  |  提交时间:2020/07/28
copper  copper zinc superoxide dismutase  cytochrome c oxidase  dopamine beta monooxygenase  elesclomol  monophenol monooxygenase  protein lysine 6 oxidase  copper  cytochrome c oxidase  elesclomol  hydrazine derivative  copper  cytochrome  enzyme  enzyme activity  mitochondrion  mortality  mutation  pathology  rodent  survival  animal cell  animal experiment  animal model  animal tissue  Article  cohort analysis  controlled study  disease severity  drug mechanism  Golgi complex  H9c2(2-1) cell line  in vivo study  male  Menkes syndrome  mitochondrial dynamics  mortality rate  mouse  nerve degeneration  nonhuman  priority journal  secretory pathway  survival rate  animal  brain  cell line  degenerative disease  disease model  drug effect  genetics  knockout mouse  Menkes syndrome  metabolism  mitochondrion  pathology  rat  transport at the cellular level  Murinae  Mus  Animals  Biological Transport  Brain  Cell Line  Copper  Copper Transporter 1  Disease Models, Animal  Electron Transport Complex IV  Hydrazines  Male  Menkes Kinky Hair Syndrome  Mice  Mice, Knockout  Mitochondria  Neurodegenerative Diseases  Rats  
Overcoming obstacles to experiments in legall practice 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:  Lynch H.F.;  Greiner D.J.;  Cohen I.G.
收藏  |  浏览/下载:23/0  |  提交时间:2020/07/28
experiment  legal system  policy approach  research  Article  clinical research  criminal justice  domestic violence  ethics  evidence based practice  health care quality  human  jurisprudence  legal aspect  legal service  medical profession  patient care  politics  priority journal  public policy  randomization  social responsibility  social support  
Mechanisms generating cancer genome complexity from a single cell division error 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Umbreit N.T.;  Zhang C.-Z.;  Lynch L.D.;  Blaine L.J.;  Cheng A.M.;  Tourdot R.;  Sun L.;  Almubarak H.F.;  Judge K.;  Mitchell T.J.;  Spektor A.;  Pellman D.
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/28
myosin adenosine triphosphatase  cancer  chromosome  detection method  DNA  error correction  gene expression  genome  genomics  mutation  Article  cell division  cellular, subcellular and molecular biological phenomena and functions  chromosome breakage  chromosome breakage fusion bridge  chromosome bridge formation  chromosomes and chromosomal phenomena  chromothripsis  DNA damage  DNA replication  human  interphase  malignant neoplasm  micronucleus  mitosis  oncogenomics  priority journal  single cell division error  
Ethics of controlled human infection to address COVID-19 期刊论文
, 2020, 卷号: 368, 期号: 6493
作者:  Shah S.K.;  Miller F.G.;  Darton T.C.;  Duenas D.;  Emerson C.;  Lynch H.F.;  Jamrozik E.;  Jecker N.S.;  Kamuya D.;  Kapulu M.;  Kimmelman J.;  MacKay D.;  Memoli M.J.;  Murphy S.C.;  Palacios R.;  Richie T.L.;  Roestenberg M.;  Saxena A.;  Saylor K.;  Selgelid M.J.;  Vaswani V.;  Rid A.
收藏  |  浏览/下载:43/0  |  提交时间:2020/07/28
epidemic  infectivity  public health  viral disease  virus vaccine  Betacoronavirus  Coronavirus infection  drug development  ethics  human  human experiment  immunology  pandemic  physiology  risk assessment  virus pneumonia  Betacoronavirus  Coronavirus Infections  Drug Development  Human Experimentation  Humans  Pandemics  Pneumonia, Viral  Risk Assessment  Viral Vaccines