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| Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者: Ebright R.Y.; Lee S.; Wittner B.S.; Niederhoffer K.L.; Nicholson B.T.; Bardia A.; Truesdell S.; Wiley D.F.; Wesley B.; Li S.; Mai A.; Aceto N.; Vincent-Jordan N.; Szabolcs A.; Chirn B.; Kreuzer J.; Comaills V.; Kalinich M.; Haas W.; Ting D.T.; Toner M.; Vasudevan S.; Haber D.A.; Maheswaran S.; Micalizzi D.S.
  收藏 | 浏览/下载：47/0 | 提交时间：2020/07/28
CRISPR associated protein epidermal growth factor receptor 2 Ki 67 antigen ribosome protein ribosome RNA transcription factor E2F ribosome protein cancer cell gene expression genetic engineering protein RNA tumor animal experiment animal model animal tissue Article biogenesis bioluminescence breast cancer cell cycle progression cell cycle regulation cell proliferation circulating tumor cell controlled study enzyme activation epithelial mesenchymal transition gene expression profiling genetic transcription human human cell lung metastasis metastasis microfluidics mouse nonhuman overall survival phenotype priority journal progression free survival promoter region protein expression protein processing protein synthesis proteomics RNA sequence transcription regulation animal breast tumor cancer transplantation CRISPR Cas system female gene expression regulation genetics pathology sequence analysis tumor cell line tumor embolism Mus Animals Breast Neoplasms Cell Line, Tumor CRISPR-Cas Systems Female Gene Expression Regulation, Neoplastic Humans Mice Neoplasm Metastasis Neoplasm Transplantation Neoplastic Cells, Circulating Ribosomal Proteins Sequence Analysis, RNA |
| Peptide signaling for drought-induced tomato flower drop 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者: Reichardt S.; Piepho H.-P.; Stintzi A.; Schaller A.
收藏 | 浏览/下载：24/0 | 提交时间：2020/07/28
mitogen activated protein kinase peptide hormone phytaspase 2 phytosulfokine unclassified drug abscission aspartic acid crop yield drought stress enzyme activity flower fruit gene expression hormone peptide abscission Arabidopsis Article bioassay cell separation controlled study cytokine production down regulation drought environmental stress enzyme activity enzyme specificity ERF4 gene ERT10 gene flower hydrolysis hydrophobicity IAA3 gene immunomodulation molecular dynamics nonhuman peptide signaling PK7 gene plant development plant genome priority journal productivity protein cleavage protein degradation protein expression protein function protein processing regulator gene signal transduction tomato TPRP gene Lycopersicon esculentum |
| De novo design of protein logic gates 期刊论文
, 2020, 卷号: 368, 期号: 6486
作者: Chen Z.; Kibler R.D.; Hunt A.; Busch F.; Pearl J.; Jia M.; VanAernum Z.L.; Wicky B.I.M.; Dods G.; Liao H.; Wilken M.S.; Ciarlo C.; Green S.; El-Samad H.; Stamatoyannopoulos J.; Wysocki V.H.; Jewett M.C.; Boyken S.E.; Baker D.
收藏 | 浏览/下载：26/0 | 提交时间：2020/07/28
cell design method gene expression genetic analysis protein activation domain Article binding affinity circular dichroism controlled study de novo design design DNA binding motif enzyme activity genetic transcription human human cell hydrogen bond hydrophobicity mass spectrometry native mass spectrometry nonhuman priority journal protein protein interaction protein structure RNA translation stoichiometry thermodynamics two hybrid system X ray crystallography chemistry genetics logic metabolism protein analysis protein engineering protein processing synthetic biology T lymphocyte yeast HAVCR2 protein, human hepatitis A virus cellular receptor 2 Hepatitis A Virus Cellular Receptor 2 Humans Logic Mass Spectrometry Protein Engineering Protein Interaction Maps Protein Processing, Post-Translational Synthetic Biology T-Lymphocytes Transcription, Genetic Yeasts |
| Total synthesis reveals atypical atropisomerism in a small-molecule natural product, tryptorubin A 期刊论文
, 2020, 卷号: 367, 期号: 6476
作者: Reisberg S.H.; Gao Y.; Walker A.S.; Helfrich E.J.N.; Clardy J.; Baran P.S.
收藏 | 浏览/下载：34/0 | 提交时间：2020/07/28
alkaloid tryptorubin A unclassified drug alkaloid connectivity molecular analysis peptide alkylation Article bioinformatics carbon nuclear magnetic resonance chemical structure chirality cyclization dehydrogenation high performance liquid chromatography hydrogen bond hydrophobicity isomerism nonhuman nuclear magnetic resonance spectroscopy oxidation priority journal protein processing proton nuclear magnetic resonance stereochemistry Streptomyces synthesis X ray crystallography |
| Phase separation provides a mechanism to reduce noise in cells 期刊论文
, 2020, 卷号: 367, 期号: 6476
作者: Klosin A.; Oltsch F.; Harmon T.; Honigmann A.; Jülicher F.; Hyman A.A.; Zechner C.
收藏 | 浏览/下载：30/0 | 提交时间：2020/07/28
cell concentration (composition) noise phase transition protein separation article controlled study mammal cell noise reduction phase separation physical model signal processing theoretical study Mammalia |
| An atlas of the protein-coding genes in the human, pig, and mouse brain 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Sjöstedt E.; Zhong W.; Fagerberg L.; Karlsson M.; Mitsios N.; Adori C.; Oksvold P.; Edfors F.; Limiszewska A.; Hikmet F.; Huang J.; Du Y.; Lin L.; Dong Z.; Yang L.; Liu X.; Jiang H.; Xu X.; Wang J.; Yang H.; Bolund L.; Mardinoglu A.; Zhang C.; von Feilitzen K.; Lindskog C.; Pontén F.; Luo Y.; Hökfelt T.; Uhlén M.; Mulder J.
收藏 | 浏览/下载：27/0 | 提交时间：2020/07/28
nerve protein transcriptome animal antibody specificity book brain C57BL mouse comparative study female gene expression regulation genetics human information processing male mouse physiology pig species difference Animals Atlases as Topic Brain Datasets as Topic Female Gene Expression Regulation Humans Male Mice Mice, Inbred C57BL Nerve Tissue Proteins Organ Specificity Species Specificity Swine Transcriptome |
| ZGLP1 is a determinant for the oogenic fate in mice 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Nagaoka S.I.; Nakaki F.; Miyauchi H.; Nosaka Y.; Ohta H.; Yabuta Y.; Kurimoto K.; Hayashi K.; Nakamura T.; Yamamoto T.; Saitou M.
收藏 | 浏览/下载：45/0 | 提交时间：2020/07/28
bone morphogenetic protein bone cell gametogenesis germ cell maturation rodent signaling adult animal cell animal experiment animal model Article cell fate controlled study embryo female gain of function mutation gene gene overexpression genetic transcription in vitro study in vivo study loss of function mutation male meiotic prophase I mouse mouse embryonic stem cell nonhuman oocyte development priority journal retroposon RNA processing RNA sequencing signal transduction spermatogenesis Stra8 gene ZGLP1 gene Mammalia Mus |
| Liquid droplets in the skin 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者: Rai A.; Pelkmans L.
收藏 | 浏览/下载：22/0 | 提交时间：2020/07/28
keratin keratohyalin profilaggrin filaggrin keratohyalin polyadenylic acid binding protein droplet membrane physiological response separation skin cell component cell organelle physiology protein acidification Article cell culture cell differentiation cell protection cell structure epidermis human keratinocyte nonhuman permeability barrier pH phase separation priority journal protein aggregation protein expression protein phosphorylation protein processing skin cell skin permeability stoichiometry stratum corneum tissue differentiation liquid crystal skin surface property calcium cell level cell compartmentalization degenerative disease environmental stress epidermis cell ichthyosis vulgaris iquid liquid phase separation keratinocyte macromolecular crowding protein cross linking protein degradation Short Survey signal transduction Liquid Crystals Skin Surface Properties |
| Next-generation epigenetic inhibitors 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者: Filippakopoulos P.; Knapp S.
收藏 | 浏览/下载：16/0 | 提交时间：2020/07/28
biological marker bromodomain inhibitor DNA experiment genetic analysis inhibitor Article binding site down regulation gene expression histone modification human nonhuman pleiotropy priority journal protein domain protein folding protein interaction protein processing protein targeting transcription elongation transcription regulation |
| Democratizing cryo-EM: Broadening access to an expanding field 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者: Tachibana C.
收藏 | 浏览/下载：116/0 | 提交时间：2020/07/28
membrane protein nucleic acid democratization detection method electron microscopy algorithm Article conformational transition cryoelectron microscopy crystallization electron diffraction electron tomography freezing glycosylation human microcrystal electron diffraction nanoimaging nuclear magnetic resonance spectroscopy priority journal protein processing protein structure protein synthesis social welfare transmission electron microscopy X ray crystallography |
