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Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Walton R.T.;  Christie K.A.;  Whittaker M.N.;  Kleinstiver B.P.
收藏  |  浏览/下载：27/0  |  提交时间：2020/07/28
adenine  adenosine  CRISPR associated endonuclease Cas9  cytosine  guanosine  SpG protein  SpRY nuclease  thymine  unclassified drug  Cas9 endonuclease Streptococcus pyogenes  bacterium  enzyme activity  genetic engineering  genetic variation  genome  Article  CRISPR-CAS9 system  DNA sequence  enzyme activity  gene editing  gene targeting  genetic variability  human  mutagenesis  nonhuman  priority journal  protein engineering  protein motif  protein structure  protospacer adjacent motif  Streptococcus pyogenes  chemistry  CRISPR Cas system  enzyme specificity  gene editing  gene targeting  genetic predisposition  genetics  HEK293 cell line  procedures  protein domain  Streptococcus pyogenes  CRISPR-Associated Protein 9  CRISPR-Cas Systems  Gene Editing  Gene Targeting  Genetic Predisposition to Disease  HEK293 Cells  Humans  Mutagenesis  Protein Domains  Substrate Specificity  
Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  [无可用作者姓名]
收藏  |  浏览/下载：48/0  |  提交时间：2020/07/28
Hrd1 ubiquitin ligase complex  Hrd3 protein  membrane protein  polypeptide  rhomboid like Der1 protein  ubiquitin protein ligase  unclassified drug  Yos9 protein  biodegradation  cell component  electron microscopy  enzyme  molecular analysis  protein  ultrastructure  Article  binding site  carboxy terminal sequence  controlled study  cryoelectron microscopy  cytosol  endoplasmic reticulum  enzyme substrate  enzyme substrate complex  fungal strain  glycosylation  micelle  molecular dynamics  priority journal  protein cross linking  protein degradation  protein function  protein misfolding  protein structure  yeast  
Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者:  Hervas R.;  Rau M.J.;  Park Y.;  Zhang W.;  Murzin A.G.;  Fitzpatrick J.A.J.;  Scheres S.H.W.;  Si K.
收藏  |  浏览/下载：29/0  |  提交时间：2020/07/28
amyloid protein  cytoplasmic polyadenylation element binding protein  insect protein  protein Orb2  unclassified drug  adult  memory  neurology  protein  substrate  turnover  Article  cryoelectron microscopy  Drosophila  enzyme activity  hydrophilicity  hydrophobicity  memory  nerve cell  nonhuman  priority journal  protein aggregation  protein function  protein isolation  protein processing  protein structure