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| Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者: Wingler L.M.; Skiba M.A.; McMahon C.; Staus D.P.; Kleinhenz A.L.W.; Suomivuori C.-M.; Latorraca N.R.; Dror R.O.; Lefkowitz R.J.; Kruse A.C.
  收藏 | 浏览/下载：24/0 | 提交时间：2020/07/28
angiotensin 1 receptor beta arrestin G protein coupled receptor biochemistry crystal chemistry crystal structure physiological response protein signaling allosterism alpha helix amino terminal sequence Article binding affinity binding site carboxy terminal sequence conformational transition crystallization hydrogen bond molecular dynamics priority journal protein binding protein conformation protein protein interaction protein stability signal transduction thermostability |
| Ancient origins of allosteric activation in a Ser-Thr kinase 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者: Hadzipasic A.; Wilson C.; Nguyen V.; Kern N.; Kim C.; Pitsawong W.; Villali J.; Zheng Y.; Kern D.
收藏 | 浏览/下载：39/0 | 提交时间：2020/07/28
aurora A kinase microtubule associated protein TPX2 protein unclassified drug activation energy ancestry cell chemical binding experimental study fitness protein allosterism amino acid sequence Article binding affinity binding site enzyme activation enzyme activity enzyme binding enzyme localization enzyme phosphorylation gene duplication horizontal gene transfer human hydrophobicity intracellular signaling phylogenetic tree phylogeny priority journal protein binding protein localization protein protein interaction |
| Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者: Suomivuori C.-M.; Latorraca N.R.; Wingler L.M.; Eismann S.; King M.C.; Kleinhenz A.L.W.; Skiba M.A.; Staus D.P.; Kruse A.C.; Lefkowitz R.J.; Dror R.O.
收藏 | 浏览/下载：17/0 | 提交时间：2020/07/28
angiotensin 1 receptor beta arrestin 1 beta arrestin 2 G protein coupled receptor rhodopsin chemical binding design method ligand molecular analysis protein signaling allosterism Article carboxy terminal sequence conformational transition controlled study crystal structure human ligand binding molecular dynamics priority journal protein conformation signal transduction structural model |
| Ion transport and regulation in a synaptic vesicle glutamate transporter 期刊论文
, 2020, 卷号: 368, 期号: 6493
作者: Li F.; Eriksen J.; Finer-Moore J.; Chang R.; Nguyen P.; Bowen A.; Myasnikov A.; Yu Z.; Bulkley D.; Cheng Y.; Edwards R.H.; Stroud R.M.
收藏 | 浏览/下载：34/0 | 提交时间：2020/07/28
brain chemical binding chloride neurology substrate Rattus chloride chloride channel glutamic acid Slc17a6 protein, rat vesicular glutamate transporter 2 allosterism amino acid sequence animal binding site chemistry cryoelectron microscopy ion transport membrane potential metabolism pH protein domain rat synapse vesicle Allosteric Regulation Amino Acid Sequence Animals Binding Sites Chloride Channels Chlorides Cryoelectron Microscopy Glutamic Acid Hydrogen-Ion Concentration Ion Transport Membrane Potentials Protein Domains Rats Synaptic Vesicles Vesicular Glutamate Transport Protein 2 |
| A combined activation mechanism for the glucagon receptor 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2020, 卷号: 117, 期号: 27
作者: Mattedi G.; Acosta-Gutiérrez S.; Clark T.; Gervasio F.L.
收藏 | 浏览/下载：0/0 | 提交时间：2021/01/06 |
| Designing heterotropically activated allosteric conformational switches using supercharging 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2020, 卷号: 117, 期号: 10
作者: Schnatz P.J.; Brisendine J.M.; Laing C.C.; Everson B.H.; French C.A.; Molinaro P.M.; Koder R.L.
收藏 | 浏览/下载：20/0 | 提交时间：2021/01/06 |
| Direct observation of ligand migration within human hemoglobin at work 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2020, 卷号: 117, 期号: 9
作者: Shibayama N.; Sato-Tomita A.; Ohki M.; Ichiyanagi K.; Park S.-Y.
收藏 | 浏览/下载：19/0 | 提交时间：2021/01/06 |
