气候变化领域集成服务门户(CCPortal): Short-term effects of air pollution on liver function among urban adults in China

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DOI	10.1016/j.atmosenv.2020.118011
	Short-term effects of air pollution on liver function among urban adults in China
	Qiu W.; Zhou Y.; He H.; Wang B.; Mu G.; Zhou M.; Ma J.; Zhang Z.; Cao L.; Xiao L.; Yuan J.; Chen W.
发表日期	2021
ISSN	1352-2310
卷号	245
英文摘要	Background: Urban environmental air pollution has become a serious public issue in China. However, the potential adverse effects of different air pollutants on liver function are still unclear. We aimed to explore the associations of air pollutants exposure with liver function, and analyzed short-term impact in two cities with different levels of air pollution. Methods: We included 3892 residents from the Wuhan (high-pollution area)-Zhuhai (low-pollution area) cohort. Liver enzymes including alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in fasting peripheral blood were determined by a fully automatic biochemical analyzer. Individual air pollutants inhalation exposure was estimated by combining his/her daily breathing volume and the concentrations of six air pollutants, including particulate matter (PM2.5), inhalable particulate matter (PM10), nitrogen dioxide (NO2), sulfur dioxide (SO2), carbon monoxide (CO) and ozone (O3), from local ambient air monitoring stations. The associations of air pollutants with ALT and AST were evaluated using linear mixed models. Results: We found positive associations of PM2.5 (lag01-lag07), PM10 (lag01-lag07), NO2 (lag01-lag07), SO2 (lag01-lag07), CO (lag01-lag06) and O3 (lag01-lag02) with ALT and PM10 (lag04-lag07) with AST. In Wuhan, exposure to PM2.5 (lag01-lag07), PM10 (lag01-lag07), NO2 (lag01-lag07) and SO2 (lag01-lag07) was associated with increased ALT, and PM10 (lag04-lag07) and NO2 (lag01-lag03) exposure was significantly associated with increased AST. While in Zhuhai, although all six air pollutants (PM2.5 [lag01-lag07], PM10 [lag01-lag02], NO2 [lag01-lag04], SO2 [lag01-lag03], CO [lag01-lag07] and O3 [lag01-lag03]) were significantly associated with increased ALT, no pollutant was significantly associated with increased AST. Conclusions: Our results suggest that short-term exposure to air pollutants has adverse effects on liver function among urban adults. Such adverse effects last longer in high-pollution area than that in low-pollution area. © 2020
关键词	Air pollution Alanine aminotransferase Aspartate aminotransferase Liver function
语种	英语
scopus关键词	Amino acids; Carbon monoxide; Nitrogen oxides; Particles (particulate matter); Sulfur dioxide; Alanine aminotransferase; Ambient air monitoring; Aspartate aminotransferase; Biochemical analyzers; Environmental air pollution; Inhalation exposure; Linear mixed models; Short-term exposure; Air pollution; alanine aminotransferase; aspartate aminotransferase; carbon monoxide; nitrogen dioxide; ozone; sulfur dioxide; ambient air; atmospheric pollution; blood; carbon monoxide; concentration (composition); disease incidence; health risk; pollution exposure; public health; suspended particulate matter; adult; air monitoring; air pollutant; air pollution; ambient air; Article; blood sampling; China; cohort analysis; controlled study; exposure; fasting; female; human; liver function; male; middle aged; particulate matter 10; particulate matter 2.5; physical activity; priority journal; respirable particulate matter; urban population; China; Guangdong; Hubei; Wuhan; Zhuhai
来源期刊	ATMOSPHERIC ENVIRONMENT
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/248760
作者单位	Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
推荐引用方式 GB/T 7714	Qiu W.,Zhou Y.,He H.,et al. Short-term effects of air pollution on liver function among urban adults in China[J],2021,245.
APA	Qiu W..,Zhou Y..,He H..,Wang B..,Mu G..,...&Chen W..(2021).Short-term effects of air pollution on liver function among urban adults in China.ATMOSPHERIC ENVIRONMENT,245.
MLA	Qiu W.,et al."Short-term effects of air pollution on liver function among urban adults in China".ATMOSPHERIC ENVIRONMENT 245(2021).