气候变化领域集成服务门户(CCPortal): Associations between size-fractioned particulate matter and left ventricular voltage: A panel study among healthy young adults in southern China

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DOI	10.1016/j.atmosenv.2021.118395
	Associations between size-fractioned particulate matter and left ventricular voltage: A panel study among healthy young adults in southern China
	Feng D.; Cao K.; Zou J.; Bloom M.S.; Lin S.; Yu Y.; Yu H.; Zhou Y.; Liu R.-Q.; Hu L.-W.; Yang B.-Y.; Zeng X.-W.; Dong G.-H.
发表日期	2021
ISSN	1352-2310
卷号	254
英文摘要	Exposure to ambient air pollution is consistently associated with increased cardiovascular morbidity and mortality; however, the underlying pathophysiologic mechanisms remain unclear. High left ventricular voltage has been related to cardiac dysfunction.Therefore, this study aimed to investigate the association between longitudinal exposure to size-fractioned particulate matter (PM) and left ventricular voltage (assessed as the sum of the voltages of the R-wave in lead V5 [RV5] and S-wave in lead V1[SV1]) among 88 healthy, young Chinese adults. We collected weekly 12-lead electrocardiogram (ECG) and serum biomarkers from each participant five times over 35 days. The fixed point, real-time, mass concentrations of particles with aerodynamic diameters of ≤2.5 μm (PM2.5), PM1, PM0.5, and number concentrations of particles with aerodynamic diameters of ≤0.2 μm (PNC0.2), PNC0.1, and PNC0.03 were monitored in the catchment area, and linear mixed-effect models were used to estimate the associations between the size-fractioned PM exposure and ECG indices. The results showed that there was a significant association between higher size-fractioned PM levels and higher RV5+SV1 voltage within 24 h of exposure. We detected increases in the RV5+SV1 voltage of 0.060, 0.058, 0.090, 0.084, and 0.077 mV per interquartile range (IQR) PM2.5 (45.92 μg/m3; 95% confidence interval [CI] = 0.003, 0.117), PM1 (43.51 μg/m3; 95% CI = 0.003, 0.113), PNC0.2 (14.92 × 103 particles/cm3; 95% CI = 0.017, 0.163), PNC0.1 (12.79 × 103 particles/cm3; 95% CI = 0.004, 0.163), and PNC0.03 (5.43 × 103 particles/cm3; 95% CI = 0, 0.153), respectively. The associations between the RV5+SV1 voltage and size-fractioned PM exposure were stronger among participants with greater serum concentrations of monocyte chemoattractant protein-1, soluble CD40 ligand, plasminogen activator inhibitor-1, and total cholesterol, and lower high-density lipoprotein cholesterol levels. Exposure to various PM size fractions (PNC0.03-PNC0.2, and PM0.5-PM2.5) may increase the left ventricular voltage among healthy young adults, and the effects may be modified by inflammation, coagulation, and lipid biomarkers. © 2021 Elsevier Ltd
关键词	Electrocardiogram Left ventricular voltage Panel study Size-fractioned particulate matter Ultrafine particle
语种	英语
scopus关键词	Aerodynamics; Catchments; Particles (particulate matter); Aerodynamic diameters; Confidence interval; Leave ventricular voltage; Left ventricular; Panel studies; Particulate Matter; Size-fractioned particulate matter; Southern China; Ultrafine particle; Young adults; Electrocardiography; angiotensin II; biological marker; C reactive protein; carbon monoxide; CD40 ligand; cholesterol; endothelin 1; high density lipoprotein cholesterol; intercellular adhesion molecule 1; low density lipoprotein cholesterol; monocyte chemotactic protein 1; nitrogen dioxide; ozone; PADGEM protein; plasminogen activator inhibitor 1; sulfur dioxide; tumor necrosis factor; vascular cell adhesion molecule 1; ambient air; atmospheric pollution; catchment; concentration (composition); confidence interval; morbidity; particulate matter; pollution exposure; public health; spatiotemporal analysis; young population; adult; Article; China; cholesterol blood level; chronic obstructive lung disease; controlled study; electrocardiogram; enzyme linked immunosorbent assay; female; heart left ventricle; human; human experiment; human tissue; male; normal human; panel study; particulate matter 2.5; PR interval; priority journal; protein blood level; QRS interval; QTc interval; R wave; relative humidity; temperature; ultrafine particulate matter; young adult; China
来源期刊	ATMOSPHERIC ENVIRONMENT
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/248437
作者单位	Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China; Department of Cardiology, Nanhai People's Hospital, The Second School of Clinical Medicine, Southern Medical University, Foshan, 528200, China; Departments of Epidemiology and Biostatistics, University at Albany, State University of New York, Rensselaer, NY 12144, United States; Departments of Environmental Health Sciences, University at Albany, State University of New York, Rensselaer, NY 12144, United States; State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, South China Institute of Environmental Sciences, Ministry of Environmental Protection, Guangzhou, 510655, China
推荐引用方式 GB/T 7714	Feng D.,Cao K.,Zou J.,et al. Associations between size-fractioned particulate matter and left ventricular voltage: A panel study among healthy young adults in southern China[J],2021,254.
APA	Feng D..,Cao K..,Zou J..,Bloom M.S..,Lin S..,...&Dong G.-H..(2021).Associations between size-fractioned particulate matter and left ventricular voltage: A panel study among healthy young adults in southern China.ATMOSPHERIC ENVIRONMENT,254.
MLA	Feng D.,et al."Associations between size-fractioned particulate matter and left ventricular voltage: A panel study among healthy young adults in southern China".ATMOSPHERIC ENVIRONMENT 254(2021).