气候变化领域集成服务门户(CCPortal): IL-18 maintains the homeostasis of mucosal immune system via inflammasome-independent but microbiota-dependent manner

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DOI	10.1016/j.scib.2021.01.025
	IL-18 maintains the homeostasis of mucosal immune system via inflammasome-independent but microbiota-dependent manner
	Zheng X.; Liu L.; Meng G.; Zhu S.; Zhou R.; Jiang W.
发表日期	2021
ISSN	20959273
英文摘要	Inflammasomes and their product interleukin 18 (IL-18) play important roles in gut microbiota monitoring and homeostasis, and their loss of function could lead to microbiota dysbiosis and accelerate disease progression. However, the impacts of the resulting microbiota dysbiosis on the mucosal immune system are largely unknown. Here, we show that dysbiotic microbiota from Il18−/− mice induced immune cell loss in the small intestine (SI) in an inflammasome-independent manner. Cohousing experiments revealed that the immunotoxic phenotype of these microbiota was transferable to wild type (WT) mice and induced immune cell death through the receptor-interacting protein kinase 3 (RIP3)-mixed lineage kinase domain like pseudokinase (MLKL) pathway. Analysis of microbiota composition identified two types of bacteria at the genus level, Ureaplasma and Parasutterella, that accumulated in Il18−/− mice and negatively mediated changes in immune cells in the SI. Furthermore, dysbiosis in Il18−/− mice also contributed to increased susceptibility to Listeria infection. Collectively, our results demonstrate that IL-18 is essential to microbiota homeostasis and that dysbiotic microbiota could significantly shape the landscape of the immune system. © 2021 Science China Press
关键词	Dysbiosis IL-18 Immune system Inflammasome
英文关键词	Cell death; Enzymes; Mammals; Physiology; Cell loss; Disease progression; Dysbiosis; Gut microbiota; Homoeostasis; Immune cells; Inflammasome; Interleukin-18; Microbiotas; Small intestine; Immune system
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207692
作者单位	Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China; The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China; CAS Centre for Excellence in Cell and Molecular Biology, University of Science and Technology of China, Hefei, 230027, China
推荐引用方式 GB/T 7714	Zheng X.,Liu L.,Meng G.,et al. IL-18 maintains the homeostasis of mucosal immune system via inflammasome-independent but microbiota-dependent manner[J],2021.
APA	Zheng X.,Liu L.,Meng G.,Zhu S.,Zhou R.,&Jiang W..(2021).IL-18 maintains the homeostasis of mucosal immune system via inflammasome-independent but microbiota-dependent manner.Science Bulletin.
MLA	Zheng X.,et al."IL-18 maintains the homeostasis of mucosal immune system via inflammasome-independent but microbiota-dependent manner".Science Bulletin (2021).