气候变化领域集成服务门户(CCPortal): Independent and reproducible hippocampal radiomic biomarkers for multisite Alzheimer's disease: diagnosis, longitudinal progress and biological basis

CCPortal

DOI	10.1016/j.scib.2020.04.003
	Independent and reproducible hippocampal radiomic biomarkers for multisite Alzheimer's disease: diagnosis, longitudinal progress and biological basis
	Zhao K.; Ding Y.; Han Y.; Fan Y.; Alexander-Bloch A.F.; Han T.; Jin D.; Liu B.; Lu J.; Song C.; Wang P.; Wang D.; Wang Q.; Xu K.; Yang H.; Yao H.; Zheng Y.; Yu C.; Zhou B.; Zhang X.; Zhou Y.; Jiang T.; Zhang X.; Liu Y.; Alzheimer's Disease Neuroimaging Initiative; Multi-Center Alzheimer Disease Imaging Consortium
发表日期	2020
ISSN	20959273
起始页码	1103
结束页码	1113
卷号	65 期号:13
英文摘要	Hippocampal morphological change is one of the main hallmarks of Alzheimer's disease (AD). However, whether hippocampal radiomic features are robust as predictors of progression from mild cognitive impairment (MCI) to AD dementia and whether these features provide any neurobiological foundation remains unclear. The primary aim of this study was to verify whether hippocampal radiomic features can serve as robust magnetic resonance imaging (MRI) markers for AD. Multivariate classifier-based support vector machine (SVM) analysis provided individual-level predictions for distinguishing AD patients (n = 261) from normal controls (NCs; n = 231) with an accuracy of 88.21% and intersite cross-validation. Further analyses of a large, independent the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset (n = 1228) reinforced these findings. In MCI groups, a systemic analysis demonstrated that the identified features were significantly associated with clinical features (e.g., apolipoprotein E (APOE) genotype, polygenic risk scores, cerebrospinal fluid (CSF) Aβ, CSF Tau), and longitudinal changes in cognition ability; more importantly, the radiomic features had a consistently altered pattern with changes in the MMSE scores over 5 years of follow-up. These comprehensive results suggest that hippocampal radiomic features can serve as robust biomarkers for clinical application in AD/MCI, and further provide evidence for predicting whether an MCI subject would convert to AD based on the radiomics of the hippocampus. The results of this study are expected to have a substantial impact on the early diagnosis of AD/MCI. © 2020 Science China Press
关键词	Biological basis Brain biomarker Hippocampal radiomic features Independent cross-validation Multisite Alzheimer's disease MRI
英文关键词	Biomarkers; Brain; Cerebrospinal fluid; Large dataset; Neurodegenerative diseases; Risk assessment; Support vector machines; Alzheimer's disease; Apolipoprotein E (apoE); Cerebro spinal fluids; Clinical application; Individual levels; Mild cognitive impairments (MCI); Morphological changes; Systemic analysis; Diagnosis
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207323
作者单位	Brainnetome Center & National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China; School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China; School of Information Science and Engineering, Shandong Normal University, Ji'nan 250358, China; Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, United States; Department of Radiology, Tianjin Huanhu Hospital, Tianjin, 300350, China; School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, 100049, China; Center for Excellence in Brain Science and Intelligence Technology, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China; Department of Radiology, Xuanwu Hospital of C...
推荐引用方式 GB/T 7714	Zhao K.,Ding Y.,Han Y.,et al. Independent and reproducible hippocampal radiomic biomarkers for multisite Alzheimer's disease: diagnosis, longitudinal progress and biological basis[J],2020,65(13).
APA	Zhao K..,Ding Y..,Han Y..,Fan Y..,Alexander-Bloch A.F..,...&Multi-Center Alzheimer Disease Imaging Consortium.(2020).Independent and reproducible hippocampal radiomic biomarkers for multisite Alzheimer's disease: diagnosis, longitudinal progress and biological basis.Science Bulletin,65(13).
MLA	Zhao K.,et al."Independent and reproducible hippocampal radiomic biomarkers for multisite Alzheimer's disease: diagnosis, longitudinal progress and biological basis".Science Bulletin 65.13(2020).