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PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington’s disease 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 4
作者:  Morozko E.L.;  Smith-Geater C.;  Monteys A.M.;  Pradhan S.;  Lim R.G.;  Langfelder P.;  Kachemov M.;  Hill A.;  Stocksdale J.T.;  Cullis P.R.;  Wu J.;  Ochaba J.;  Miramontes R.;  Chakraborty A.;  Hazra T.K.;  Lau A.;  St-Cyr S.;  Orellana I.;  Kopan L.;  Wang K.Q.;  Yeung S.;  Leavitt B.R.;  Reidling J.C.;  William Yang X.;  Steffan J.S.;  Davidson B.L.;  Sarkar P.S.;  Thompson L.M.
收藏  |  浏览/下载：26/0  |  提交时间：2021/05/24
Cag rnas induce dna damage and apoptosis by silencing nudt16 expression in polyglutamine degeneration 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 19
作者:  Peng S.;  Guo P.;  Lin X.;  An Y.;  Sze K.H.;  Lau M.H.Y.;  Chen Z.S.;  Wang Q.;  Li W.;  Sun J.K.-L.;  Ma S.Y.;  Chan T.-F.;  Lau K.-F.;  Ngo J.C.K.;  Kwan K.M.;  Wong C.-H.;  Lam S.L.;  Zimmerman S.C.;  Tuccinardi T.;  Zuo Z.;  Au-Yeung H.Y.;  Chow H.-M.;  Chan H.Y.E.
收藏  |  浏览/下载：38/0  |  提交时间：2022/02/22
Large-scale features of Last Interglacial climate: Results from evaluating the lig127k simulations for the Coupled Model Intercomparison Project (CMIP6)-Paleoclimate Modeling Intercomparison Project (PMIP4) 期刊论文
Climate of the Past, 2021, 卷号: 17, 期号: 1
作者:  Otto-Bliesner B.L.;  Brady E.C.;  Zhao A.;  Brierley C.M.;  Axford Y.;  Capron E.;  Govin A.;  Hoffman J.S.;  Isaacs E.;  Kageyama M.;  Scussolini P.;  Tzedakis P.C.;  Williams C.J.R.;  Wolff E.;  Abe-Ouchi A.;  Braconnot P.;  Ramos Buarque S.;  Cao J.;  De Vernal A.;  Vittoria Guarino M.;  Guo C.;  Legrande A.N.;  Lohmann G.;  Meissner K.J.;  Menviel L.;  Morozova P.A.;  Nisancioglu K.H.;  O'Ishi R.;  Mélia D.S.Y.;  Shi X.;  Sicard M.;  Sime L.;  Stepanek C.;  Tomas R.;  Volodin E.;  Yeung N.K.H.;  Zhang Q.;  Zhang Z.;  Zheng W.
收藏  |  浏览/下载：24/0  |  提交时间：2021/06/28
A multi-model CMIP6-PMIP4 study of Arctic sea ice at 127 ka: Sea ice data compilation and model differences 期刊论文
Climate of the Past, 2021, 卷号: 17, 期号: 1
作者:  Kageyama M.;  Sime L.C.;  Sicard M.;  Guarino M.-V.;  De Vernal A.;  Stein R.;  Schroeder D.;  Malmierca-Vallet I.;  Abe-Ouchi A.;  Bitz C.;  Braconnot P.;  Brady E.C.;  Cao J.;  Chamberlain M.A.;  Feltham D.;  Guo C.;  Legrande A.N.;  Lohmann G.;  Meissner K.J.;  Menviel L.;  Morozova P.;  Nisancioglu K.H.;  Otto-Bliesner B.L.;  O'Ishi R.;  Buarque S.R.;  Melia D.S.Y.;  Sherriff-Tadano S.;  Stroeve J.;  Shi X.;  Sun B.;  Tomas R.A.;  Volodin E.;  Yeung N.K.H.;  Zhang Q.;  Zhang Z.;  Zheng W.;  Ziehn T.
收藏  |  浏览/下载：99/0  |  提交时间：2021/06/28
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  Gilan O.;  Rioja I.;  Knezevic K.;  Bell M.J.;  Yeung M.M.;  Harker N.R.;  Lam E.Y.N.;  Chung C.;  Bamborough P.;  Petretich M.;  Urh M.;  Atkinson S.J.;  Bassil A.K.;  Roberts E.J.;  Vassiliadis D.;  Burr M.L.;  Preston A.G.S.;  Wellaway C.;  Werner T.;  Gray J.R.;  Michon A.-M.;  Gobbetti T.;  Kumar V.;  Soden P.E.;  Haynes A.;  Vappiani J.;  Tough D.F.;  Taylor S.;  Dawson S.-J.;  Bantscheff M.;  Lindon M.;  Drewes G.;  Demont E.H.;  Daniels D.L.;  Grandi P.;  Prinjha R.K.;  Dawson M.A.
收藏  |  浏览/下载：24/0  |  提交时间：2020/07/28
7 (3,5 dimethyl 4 isoxazolyl) 1,3 dihydro 8 methoxy 1 [1 (2 pyridinyl)ethyl] 2h imidazo[4,5 c]quinolin 2 one  apremilast  bromodomain and extraterminal domain protein 1  bromodomain and extraterminal domain protein 2  bromodomain inhibitor  gsk 046  gsk 620  gsk 778  transcription factor  unclassified drug  cancer  drug  gene expression  immune response  inhibitor  physiological response  acute myeloid leukemia  animal experiment  animal model  animal tissue  antibody response  antineoplastic activity  antiproliferative activity  apoptosis  Article  binding affinity  controlled study  crystal structure  drug design  drug efficacy  drug protein binding  drug selectivity  drug specificity  drug structure  drug targeting  gene expression  high throughput screening  human  human cell  IC50  immunomodulation  in vivo study  inflammation  K-562 cell line  malignant neoplasm  MDA-MB-453 cell line  MOLM-13 cell line  mouse  nonhuman  priority journal  psoriasis