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| Induction of core symptoms of autism spectrum disorder by in vivo CRISPR/Cas9-based gene editing in the brain of adolescent rhesus monkeys 期刊论文
Science Bulletin, 2021
作者: Wu S.-H.; Li X.; Qin D.-D.; Zhang L.-H.; Cheng T.-L.; Chen Z.-F.; Nie B.-B.; Ren X.-F.; Wu J.; Wang W.-C.; Hu Y.-Z.; Gu Y.-L.; Lv L.-B.; Yin Y.; Hu X.-T.; Qiu Z.-L.
  收藏 | 浏览/下载：21/0 | 提交时间：2021/09/01
Autism spectrum disorders Disease model Gene-editing Nonhuman primate model |
| Generation of nonhuman primate retinitis pigmentosa model by in situ knockout of RHO in rhesus macaque retina 期刊论文
Science Bulletin, 2021, 卷号: 66, 期号: 4
作者: Li S.; Hu Y.; Li Y.; Hu M.; Wang W.; Ma Y.; Cai Y.; Wei M.; Yao Y.; Wang Y.; Dong K.; Gu Y.; Zhao H.; Bao J.; Qiu Z.; Zhang M.; Hu X.; Xue T.
收藏 | 浏览/下载：47/0 | 提交时间：2021/09/01
Disease model Gene editing Nonhuman primate model Retinitis pigmentosa Rhodopsin SaCas9 |
| From seed to sequence: Dematerialization and the battle to (re)define genetic resources 期刊论文
Global Environmental Change, 2021, 卷号: 68
作者: Nawaz S.; Satterfield T.; Hagerman S.
收藏 | 浏览/下载：15/0 | 提交时间：2021/09/01
Access and benefit sharing Convention on Biological Diversity Gene editing Genetic resources Nagoya Protocol Synthetic biology |
| Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Walton R.T.; Christie K.A.; Whittaker M.N.; Kleinstiver B.P.
收藏 | 浏览/下载：16/0 | 提交时间：2020/07/28
adenine adenosine CRISPR associated endonuclease Cas9 cytosine guanosine SpG protein SpRY nuclease thymine unclassified drug Cas9 endonuclease Streptococcus pyogenes bacterium enzyme activity genetic engineering genetic variation genome Article CRISPR-CAS9 system DNA sequence enzyme activity gene editing gene targeting genetic variability human mutagenesis nonhuman priority journal protein engineering protein motif protein structure protospacer adjacent motif Streptococcus pyogenes chemistry CRISPR Cas system enzyme specificity gene editing gene targeting genetic predisposition genetics HEK293 cell line procedures protein domain Streptococcus pyogenes CRISPR-Associated Protein 9 CRISPR-Cas Systems Gene Editing Gene Targeting Genetic Predisposition to Disease HEK293 Cells Humans Mutagenesis Protein Domains Substrate Specificity |
| Very fast CRISPR on demand 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者: Liu Y.; Zou R.S.; He S.; Nihongaki Y.; Li X.; Razavi S.; Wu B.; Ha T.
收藏 | 浏览/下载：20/0 | 提交时间：2020/07/28
Cas9 endonuclease Streptococcus pyogenes double strand break repair protein MRE11 H2AX protein, human histone MRE11 protein, human CRISPR Cas system DNA cleavage DNA repair double stranded DNA break fluorescence imaging gene editing genetics HEK293 cell line human light metabolism phosphorylation procedures radiation response single cell analysis CRISPR-Associated Protein 9 CRISPR-Cas Systems DNA Breaks, Double-Stranded DNA Cleavage DNA Repair Gene Editing HEK293 Cells Histones Humans Light MRE11 Homologue Protein Optical Imaging Phosphorylation Single-Cell Analysis |
| CRISPR-engineered T cells in patients with refractory cancer 期刊论文
, 2020, 卷号: 367, 期号: 6481
作者: Stadtmauer E.A.; Fraietta J.A.; Davis M.M.; Cohen A.D.; Weber K.L.; Lancaster E.; Mangan P.A.; Kulikovskaya I.; Gupta M.; Chen F.; Tian L.; Gonzalez V.E.; Xu J.; Jung I.-Y.; Joseph Melenhorst J.; Plesa G.; Shea J.; Matlawski T.; Cervini A.; Gaymon A.L.; Desjardins S.; Lamontagne A.; Salas-Mckee J.; Fesnak A.; Siegel D.L.; Levine B.L.; Jadlowsky J.K.; Young R.M.; Chew A.; Hwang W.-T.; Hexner E.O.; Carreno B.M.; Nobles C.L.; Bushman F.D.; Parker K.R.; Qi Y.; Satpathy A.T.; Chang H.Y.; Zhao Y.; Lacey S.F.; June C.H.
收藏 | 浏览/下载：36/0 | 提交时间：2020/07/28
heterodimer programmed death 1 receptor T lymphocyte receptor alpha chain T lymphocyte receptor beta chain cancer cell gene gene expression genetic engineering immunity protein adult aged Article cancer patient cell engineering chromosome translocation clinical article clustered regularly interspaced short palindromic repeat controlled study CRISPR-CAS9 system feasibility study female gene editing gene expression gene frequency gene locus genetic code human human cell male middle aged myeloma PDCD1 gene phase 1 clinical trial priority journal sarcoma T lymphocyte TRAC gene TRBC gene tumor immunity |
| Hope for hematological diseases 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者: Wilkinson A.C.
收藏 | 浏览/下载：30/0 | 提交时间：2020/07/28
fibronectin polyvinyl alcohol serum albumin stem cell factor thrombopoietin blood disease incidence disease treatment laboratory method medicine public health Article cell differentiation cell self-renewal chemotherapy CRISPR-CAS9 system ex vivo study gene editing gene therapy genotoxicity graft versus host reaction hematologic disease hematopoiesis hematopoietic stem cell transplantation human morbidity mortality multipotent stem cell nonhuman priority journal radiotherapy stem cell culture stem cell expansion |
| Supramolecular attack particles are autonomous killing entities released from cytotoxic T cells 期刊论文
, 2020, 卷号: 368, 期号: 6493
作者: Bálint Š.; Müller S.; Fischer R.; Kessler B.M.; Harkiolaki M.; Valitutti S.; Dustin M.L.
收藏 | 浏览/下载：32/0 | 提交时间：2020/07/28
cancer cell identification method molecular analysis reconstruction granzyme multiprotein complex perforin thrombospondin 1 CRISPR Cas system cytotoxic T lymphocyte cytotoxicity exocytosis gene editing genetics human K-562 cell line metabolism x-ray tomography CRISPR-Cas Systems Cytotoxicity, Immunologic Exocytosis Gene Editing Granzymes Humans K562 Cells Multiprotein Complexes Perforin T-Lymphocytes, Cytotoxic Thrombospondin 1 Tomography, X-Ray |
| Towards Exploitation of Adaptive Traits for Climate-Resilient Smart Pulses 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 卷号: 20, 期号: 12
作者: Kumar, Jitendra; Choudhary, Arbind K.; Sen Gupta, Debjyoti; Kumar, Shiv
收藏 | 浏览/下载：20/0 | 提交时间：2019/10/08
adaptive traits gene QTL epigenetics transgenics genome editing climate-smart pulses |
| Plant synthetic biology could drive a revolution in biofuels and medicine 期刊论文
EXPERIMENTAL BIOLOGY AND MEDICINE, 2019, 卷号: 244, 期号: 4, 页码: 323-331
作者: Mortimer, Jenny C.
收藏 | 浏览/下载：14/0 | 提交时间：2019/10/08
Biofuels gene editing genetic engineering plant produced vaccines plant synthetic biology renewable chemicals |
