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Effect of tolerance on the evolution of antibiotic resistance under drug combinations 期刊论文
, 2020, 卷号: 367, 期号: 6474
作者:  Liu J.;  Gefen O.;  Ronin I.;  Bar-Meir M.;  Balaban N.Q.
收藏  |  浏览/下载：12/0  |  提交时间：2020/07/28
daptomycin  rifampicin  vancomycin  antiinfective agent  beta' subunit of RNA polymerase  daptomycin  DNA directed RNA polymerase  rifampicin  vancomycin  antibiotic resistance  bacterium  emergence  evolutionary biology  experimental study  laboratory method  survival  adult  antibiotic resistance  Article  bacterial mutation  bacterial strain  bacterium isolation  clinical article  colony forming unit  combination drug therapy  drug effect  drug tolerance  human  in vitro study  minimum inhibitory concentration  nonhuman  phylogeny  priority journal  Staphylococcus aureus  whole genome sequencing  antibiotic resistance  combination drug therapy  drug effect  genetics  methicillin resistant Staphylococcus aureus  microbial sensitivity test  microbiology  molecular evolution  mutation  single nucleotide polymorphism  Staphylococcus infection  Staphylococcus aureus  Anti-Bacterial Agents  Daptomycin  DNA-Directed RNA Polymerases  Drug Resistance, Microbial  Drug Therapy, Combination  Evolution, Molecular  Humans  Methicillin-Resistant Staphylococcus aureus  Microbial Sensitivity Tests  Mutation  Polymorphism, Single Nucleotide  Rifampin  Staphylococcal Infections  Vancomycin  
Pulmonary surfactant-biomimetic nanoparticles potentiate heterosubtypic influenza immunity 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  Wang J.;  Li P.;  Yu Y.;  Fu Y.;  Jiang H.;  Lu M.;  Sun Z.;  Jiang S.;  Lu L.;  Wu M.X.
收藏  |  浏览/下载：33/0  |  提交时间：2020/07/28
2',3' cyclic guanosine monophosphate adenosine monophosphate  influenza vaccine  interferon  nanoparticle  pulmonary surfactant biomimetic nanoparticle  purine nucleotide  surfactant protein A  surfactant protein D  unclassified drug  cell  drug resistance  immune response  immunity  induced response  influenza  nanoparticle  rodent  surfactant  vaccine  animal cell  animal experiment  animal model  animal tissue  Article  CD8+ T lymphocyte  cellular immunity  controlled study  cross protection  cytokine response  drug efficacy  drug safety  drug synthesis  female  human  humoral immunity  hydrophilicity  immune response  immunopathology  immunosurveillance  influenza  innate immunity  lung alveolus epithelium cell  lung alveolus macrophage  mouse  Mustela putorius furo  nanoencapsulation  nonhuman  priority journal  Mus  Mustela  
An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors 期刊论文
, 2020, 卷号: 367, 期号: 6476
作者:  Reinhard K.;  Rengstl B.;  Oehm P.;  Michel K.;  Billmeier A.;  Hayduk N.;  Klein O.;  Kuna K.;  Ouchan Y.;  Wöll S.;  Christ E.;  Weber D.;  Suchan M.;  Bukur T.;  Birtel M.;  Jahndel V.;  Mroz K.;  Hobohm K.;  Kranz L.;  Diken M.;  Kühlcke K.;  Türeci Ö.;  Sahin U.
收藏  |  浏览/下载：34/0  |  提交时间：2020/07/28
chimeric antigen receptor  claudin 6  RNA vaccine  antigen  cell component  protein  RNA  tumor  vaccine  animal cell  animal experiment  animal model  animal tissue  antigen presenting cell  antineoplastic activity  Article  cell stimulation  cell transport  chimeric antigen receptor T-cell immunotherapy  controlled study  drug efficacy  human  human cell  in vivo study  mouse  nonhuman  phenotype  priority journal  real time polymerase chain reaction  solid malignant neoplasm  therapy effect  vaccination coverage  
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  Gilan O.;  Rioja I.;  Knezevic K.;  Bell M.J.;  Yeung M.M.;  Harker N.R.;  Lam E.Y.N.;  Chung C.;  Bamborough P.;  Petretich M.;  Urh M.;  Atkinson S.J.;  Bassil A.K.;  Roberts E.J.;  Vassiliadis D.;  Burr M.L.;  Preston A.G.S.;  Wellaway C.;  Werner T.;  Gray J.R.;  Michon A.-M.;  Gobbetti T.;  Kumar V.;  Soden P.E.;  Haynes A.;  Vappiani J.;  Tough D.F.;  Taylor S.;  Dawson S.-J.;  Bantscheff M.;  Lindon M.;  Drewes G.;  Demont E.H.;  Daniels D.L.;  Grandi P.;  Prinjha R.K.;  Dawson M.A.
收藏  |  浏览/下载：26/0  |  提交时间：2020/07/28
7 (3,5 dimethyl 4 isoxazolyl) 1,3 dihydro 8 methoxy 1 [1 (2 pyridinyl)ethyl] 2h imidazo[4,5 c]quinolin 2 one  apremilast  bromodomain and extraterminal domain protein 1  bromodomain and extraterminal domain protein 2  bromodomain inhibitor  gsk 046  gsk 620  gsk 778  transcription factor  unclassified drug  cancer  drug  gene expression  immune response  inhibitor  physiological response  acute myeloid leukemia  animal experiment  animal model  animal tissue  antibody response  antineoplastic activity  antiproliferative activity  apoptosis  Article  binding affinity  controlled study  crystal structure  drug design  drug efficacy  drug protein binding  drug selectivity  drug specificity  drug structure  drug targeting  gene expression  high throughput screening  human  human cell  IC50  immunomodulation  in vivo study  inflammation  K-562 cell line  malignant neoplasm  MDA-MB-453 cell line  MOLM-13 cell line  mouse  nonhuman  priority journal  psoriasis  
Structural basis for strand-transfer inhibitor binding to HIV intasomes 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  Passos D.O.;  Li M.;  Jóźwik I.K.;  Zhao X.Z.;  Santos-Martins D.;  Yang R.;  Smith S.J.;  Jeon Y.;  Forli S.;  Hughes S.H.;  Burke T.R.;  Jr.;  Craigie R.;  Lyumkis D.
收藏  |  浏览/下载：16/0  |  提交时间：2020/07/28
bictegravir  nucleoprotein  protein intasome  unclassified drug  viral protein  bictegravir  fused heterocyclic rings  integrase  integrase inhibitor  multiprotein complex  naphthyridine derivative  nucleoprotein  biochemistry  chemical binding  human immunodeficiency virus  inhibitor  protein  ultrastructure  amino terminal sequence  Article  carboxy terminal sequence  catalysis  cryoelectron microscopy  drug design  drug efficacy  drug protein binding  drug resistance  drug structure  enzyme active site  human  Human immunodeficiency virus infection  nonhuman  priority journal  protein purification  protein structure  antiviral resistance  chemistry  drug effect  genetics  Human immunodeficiency virus  virus DNA cell DNA interaction  Cryoelectron Microscopy  Drug Design  Drug Resistance, Viral  Heterocyclic Compounds, 4 or More Rings  HIV  HIV Integrase  HIV Integrase Inhibitors  Humans  Multiprotein Complexes  Naphthyridines  Nucleoproteins  Virus Integration