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期刊论文 [6]
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2020 [6]
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英语 [6]
来源机构
Science [6]
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CFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation
期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:
Muendlein H.I.
;
Jetton D.
;
Connolly W.M.
;
Eidell K.P.
;
Magri Z.
;
Smirnova I.
;
Poltorak A.
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/07/28
FLICE inhibitory protein
interleukin 1beta
lipopolysaccharide
messenger RNA
succinate dehydrogenase (ubiquinone)
Casp1 protein, mouse
caspase 8
Cflar protein, mouse
cryopyrin
FLICE inhibitory protein
IL1B protein, mouse
inflammasome
interleukin 1beta
interleukin 1beta converting enzyme
lipopolysaccharide
succinate dehydrogenase (ubiquinone)
cell
enzyme activity
inhibition
maturation
protein
animal cell
animal experiment
Article
bone marrow derived macrophage
cell death
cell protection
complex formation
controlled study
cytokine release
in vitro study
inflammation
mouse
nonhuman
priority journal
protein analysis
protein degradation
protein function
protein interaction
pyroptosis
animal
gene knockdown
genetics
immunology
macrophage
macrophage activation
metabolism
physiology
Murinae
Animals
CASP8 and FADD-Like Apoptosis Regulating Protein
Caspase 1
Caspase 8
Electron Transport Complex II
Gene Knockdown Techniques
Inflammasomes
Interleukin-1beta
Lipopolysaccharides
Macrophage Activation
Macrophages
Mice
NLR Family, Pyrin Domain-Containing 3 Protein
Pyroptosis
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells
期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:
Zhou Z.
;
He H.
;
Wang K.
;
Shi X.
;
Wang Y.
;
Su Y.
;
Wang Y.
;
Li D.
;
Liu W.
;
Zhang Y.
;
Shen L.
;
Han W.
;
Shen L.
;
Ding J.
;
Shao F.
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/07/28
cell
cell component
cytology
enzyme
enzyme activity
gene expression
immunity
tumor
Mus
gamma interferon
granzyme
GSDMB protein, human
GZMA protein, human
pore forming cytotoxic protein
tumor protein
animal
Bagg albino mouse
chemistry
cytotoxic T lymphocyte
enzymology
genetics
HEK293 cell line
human
immunology
metabolism
mouse
natural killer cell
neoplasm
pathology
protein degradation
protein domain
pyroptosis
transgenic mouse
Animals
Granzymes
HEK293 Cells
Humans
Interferon-gamma
Killer Cells, Natural
Mice
Mice, Inbred BALB C
Mice, Transgenic
Neoplasm Proteins
Neoplasms
Pore Forming Cytotoxic Proteins
Protein Domains
Proteolysis
Pyroptosis
T-Lymphocytes, Cytotoxic
The body's dangerous defenders
期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:
Leslie M.
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/28
alvelestat
avacopan
chemokine receptor CXCR2
danirixin
leukocyte elastase
n [2 (2,3 difluorobenzylthio) 6 (2,3 dihydroxy 1 methylpropoxy) 4 pyrimidinyl] 1 azetidinesulfonamide
nemiralisib
simvastatin
leukocyte elastase inhibitor
antimicrobial activity
apoptosis
cell
enzyme activity
physiological response
ANCA associated vasculitis
Article
autoimmune disease
autoimmunity
bacterial pneumonia
bactericidal activity
bronchiolitis obliterans
drug targeting
extracellular matrix
extracellular trap
hematopoietic stem cell transplantation
human
immunity
immunocompetent cell
infection
inflammation
lung disease
neutrophil
neutrophil chemotaxis
nonhuman
priority journal
risk factor
sepsis
single cell RNA seq
autoimmune disease
chronic obstructive lung disease
clinical trial (topic)
drug effect
enzymology
immunology
lung tumor
neutrophil
Autoimmune Diseases
Clinical Trials as Topic
Humans
Lung Neoplasms
Neutrophils
Proteinase Inhibitory Proteins, Secretory
Pulmonary Disease, Chronic Obstructive
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation
期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:
Gilan O.
;
Rioja I.
;
Knezevic K.
;
Bell M.J.
;
Yeung M.M.
;
Harker N.R.
;
Lam E.Y.N.
;
Chung C.
;
Bamborough P.
;
Petretich M.
;
Urh M.
;
Atkinson S.J.
;
Bassil A.K.
;
Roberts E.J.
;
Vassiliadis D.
;
Burr M.L.
;
Preston A.G.S.
;
Wellaway C.
;
Werner T.
;
Gray J.R.
;
Michon A.-M.
;
Gobbetti T.
;
Kumar V.
;
Soden P.E.
;
Haynes A.
;
Vappiani J.
;
Tough D.F.
;
Taylor S.
;
Dawson S.-J.
;
Bantscheff M.
;
Lindon M.
;
Drewes G.
;
Demont E.H.
;
Daniels D.L.
;
Grandi P.
;
Prinjha R.K.
;
Dawson M.A.
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/07/28
7 (3,5 dimethyl 4 isoxazolyl) 1,3 dihydro 8 methoxy 1 [1 (2 pyridinyl)ethyl] 2h imidazo[4,5 c]quinolin 2 one
apremilast
bromodomain and extraterminal domain protein 1
bromodomain and extraterminal domain protein 2
bromodomain inhibitor
gsk 046
gsk 620
gsk 778
transcription factor
unclassified drug
cancer
drug
gene expression
immune response
inhibitor
physiological response
acute myeloid leukemia
animal experiment
animal model
animal tissue
antibody response
antineoplastic activity
antiproliferative activity
apoptosis
Article
binding affinity
controlled study
crystal structure
drug design
drug efficacy
drug protein binding
drug selectivity
drug specificity
drug structure
drug targeting
gene expression
high throughput screening
human
human cell
IC50
immunomodulation
in vivo study
inflammation
K-562 cell line
malignant neoplasm
MDA-MB-453 cell line
MOLM-13 cell line
mouse
nonhuman
priority journal
psoriasis
An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis
期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:
Zhao P.
;
Sun X.
;
Chaggan C.
;
Liao Z.
;
Wong K.I.
;
He F.
;
Singh S.
;
Loomba R.
;
Karin M.
;
Witztum J.L.
;
Saltiel A.R.
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/28
6,7 dihydro 4 hydroxy 3 (2' hydroxy 1,1' biphenyl 4 yl) 6 oxothieno[2,3 b]pyridine 5 carbonitrile
adenosine phosphate
caspase 3
caspase 6
caspase 7
cytochrome c
hydroxymethylglutaryl coenzyme A reductase kinase
matrix metalloproteinase
apoptosis
cytochrome
enzyme
enzyme activity
inhibition
protein
rodent
AMPK signaling
animal experiment
animal model
animal tissue
apoptosis
Article
C57BL 6 mouse
cell death
controlled study
drug mechanism
enzyme activation
enzyme activity
enzyme inhibition
enzyme phosphorylation
enzyme repression
gene knockout
human
human cell
human tissue
liver cell
liver fibrosis
liver injury
male
mouse
nonalcoholic steatohepatitis
nonhuman
priority journal
protein cleavage
protein secretion
Programmed cell death along the midline axis patterns ipsilaterality in gastrulation
期刊论文
, 2020, 卷号: 367, 期号: 6474
作者:
Maya-Ramos L.
;
Mikawa T.
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/07/28
apoptosis
cell
embryonic development
functional role
inhibition
symmetry
transformation
apoptosis
article
bird
cell migration
cell transformation
embryo
extracellular matrix
gastrulation
germ layer
human
nonhuman
animal
cell motion
chick embryo
epithelial mesenchymal transition
transgenic animal
Animalia
Aves
green fluorescent protein
Animals
Animals, Genetically Modified
Apoptosis
Cell Movement
Chick Embryo
Epithelial-Mesenchymal Transition
Extracellular Matrix
Gastrulation
Green Fluorescent Proteins