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Efficacy and safety of chiglitazar, a novel peroxisome proliferator-activated receptor pan-agonist, in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, phase 3 trial (CMAP) 期刊论文
Science Bulletin, 2021, 卷号: 66, 期号: 15
作者:  Ji L.;  Song W.;  Fang H.;  Li W.;  Geng J.;  Wang Y.;  Guo L.;  Cai H.;  Yang T.;  Li H.;  Yang G.;  Li Q.;  Liu K.;  Li S.;  Liu Y.;  Shi F.;  Li X.;  Gao X.;  Tian H.;  Ji Q.;  Su Q.;  Zhou Z.;  Wang W.;  Zhou Z.;  Li X.;  Xu Y.;  Ning Z.;  Cao H.;  Pan D.;  Yao H.;  Lu X.;  Jia W.
收藏  |  浏览/下载：35/0  |  提交时间：2021/09/01
Carfloglitazar  Chiglitazar  Glycemic control  Insulin resistance  PPAR pan-agonist  Type 2 diabetes  
Chiglitazar monotherapy with sitagliptin as an active comparator in patients with type 2 diabetes: a randomized, double-blind, phase 3 trial (CMAS) 期刊论文
Science Bulletin, 2021, 卷号: 66, 期号: 15
作者:  Jia W.;  Ma J.;  Miao H.;  Wang C.;  Wang X.;  Li Q.;  Lu W.;  Yang J.;  Zhang L.;  Yang J.;  Wang G.;  Zhang X.;  Zhang M.;  Sun L.;  Yu X.;  Du J.;  Shi B.;  Xiao C.;  Zhu D.;  Liu H.;  Zhong L.;  Xu C.;  Xu Q.;  Liang G.;  Zhang Y.;  Li G.;  Gu M.;  Liu J.;  Yuan G.;  Yan Z.;  Yan D.;  Ye S.;  Zhang F.;  Ning Z.;  Cao H.;  Pan D.;  Yao H.;  Lu X.;  Ji L.
收藏  |  浏览/下载：38/0  |  提交时间：2021/09/01
Chiglitazar  Glycemic control  Insulin resistance  PPAR pan-agonist  Type 2 diabetes  
Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 9
作者:  Wang M.-Y.;  Dean E.D.;  Quittner-Strom E.;  Zhu Y.;  Chowdhury K.H.;  Zhang Z.;  Zhao S.;  Li N.;  Ye R.;  Lee Y.;  Zhang Y.;  Chen S.;  Yu X.;  Leonard D.C.;  Poffenberger G.;  Deylen A.V.;  McCorkle S.K.;  Schlegel A.;  Sloop K.W.;  Efanov A.M.;  Gimeno R.E.;  Scherer P.E.;  Powers A.C.;  Unger R.H.;  Holland W.L.
收藏  |  浏览/下载：29/0  |  提交时间：2021/05/24
Electrogenetic cellular insulin release for real-time glycemic control in type 1 diabetic mice 期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:  Krawczyk K.;  Xue S.;  Buchmann P.;  Charpin-El-Hamri G.;  Saxena P.;  Hussherr M.-D.;  Shao J.;  Ye H.;  Xie M.;  Fussenegger M.
收藏  |  浏览/下载：33/0  |  提交时间：2020/07/28
cell  diabetes  hormone  peptide  real time  rodent  Mus  calcium channel L type  inwardly rectifying potassium channel  inwardly rectifying potassium channel subunit Kir2.1  L-type calcium channel alpha(1C)  animal  calcium signaling  cell engineering  devices  electrostimulation  experimental diabetes mellitus  genetic transcription  genetics  HEK293 cell line  human  insulin dependent diabetes mellitus  insulin release  male  metabolism  mouse  pancreas islet beta cell  prostheses and orthoses  transgene  wireless communication  Animals  Bionics  Calcium Channels, L-Type  Calcium Signaling  Cell Engineering  Diabetes Mellitus, Experimental  Diabetes Mellitus, Type 1  Electric Stimulation  HEK293 Cells  Humans  Insulin Secretion  Insulin-Secreting Cells  Male  Mice  Potassium Channels, Inwardly Rectifying  Prostheses and Implants  Transcription, Genetic  Transgenes  Wireless Technology  
The assessment report of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services on pollinators, pollination and food production 科技报告
, 2016
Adobe PDF(27155Kb)  |  收藏  |  浏览/下载：30/8  |  提交时间：2019/11/06
Inhaled ozone (O-3)-induces changes in serum metabolomic and liver transcriptomic profiles in rats 期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2015, 卷号: 286, 期号: 2, 页码: 65-79
作者:  Miller, Desinia B.;  Karoly, Edward D.;  Jones, Jan C.;  Ward, William O.;  Vallanat, Beena D.;  Andrews, Debora L.;  Schladweiler, Mette C.;  Snow, Samantha J.;  Bass, Virginia L.;  Richards, Judy E.;  Ghio, Andrew J.;  Cascio, Wayne E.;  Ledbetter, Allen D.;  Kodavanti, Urmila P.
收藏  |  浏览/下载：27/0  |  提交时间：2019/05/04