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Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells 期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:  Zhou Z.;  He H.;  Wang K.;  Shi X.;  Wang Y.;  Su Y.;  Wang Y.;  Li D.;  Liu W.;  Zhang Y.;  Shen L.;  Han W.;  Shen L.;  Ding J.;  Shao F.
收藏  |  浏览/下载：26/0  |  提交时间：2020/07/28
cell  cell component  cytology  enzyme  enzyme activity  gene expression  immunity  tumor  Mus  gamma interferon  granzyme  GSDMB protein, human  GZMA protein, human  pore forming cytotoxic protein  tumor protein  animal  Bagg albino mouse  chemistry  cytotoxic T lymphocyte  enzymology  genetics  HEK293 cell line  human  immunology  metabolism  mouse  natural killer cell  neoplasm  pathology  protein degradation  protein domain  pyroptosis  transgenic mouse  Animals  Granzymes  HEK293 Cells  Humans  Interferon-gamma  Killer Cells, Natural  Mice  Mice, Inbred BALB C  Mice, Transgenic  Neoplasm Proteins  Neoplasms  Pore Forming Cytotoxic Proteins  Protein Domains  Proteolysis  Pyroptosis  T-Lymphocytes, Cytotoxic  
A cell atlas of human thymic development defines T cell repertoire formation 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  Park J.-E.;  Botting R.A.;  Conde C.D.;  Popescu D.-M.;  Lavaert M.;  Kunz D.J.;  Goh I.;  Stephenson E.;  Ragazzini R.;  Tuck E.;  Wilbrey-Clark A.;  Roberts K.;  Kedlian V.R.;  Ferdinand J.R.;  He X.;  Webb S.;  Maunder D.;  Vandamme N.;  Mahbubani K.T.;  Polanski K.;  Mamanova L.;  Bolt L.;  Crossland D.;  De Rita F.;  Fuller A.;  Filby A.;  Reynolds G.;  Dixon D.;  Saeb-Parsy K.;  Lisgo S.;  Henderson D.;  Vento-Tormo R.;  Bayraktar O.A.;  Barker R.A.;  Meyer K.B.;  Saeys Y.;  Bonfanti P.;  Behjati S.;  Clatworthy M.R.;  Taghon T.;  Haniffa M.;  Teichmann S.A.
收藏  |  浏览/下载：53/0  |  提交时间：2020/07/28
T lymphocyte receptor  cell component  developmental biology  differentiation  genomics  recombination  RNA  adaptive immunity  Article  CD4+ T lymphocyte  CD8+ T lymphocyte  cell fate  cell maturation  cell selection  controlled study  developmental stage  gene  gene expression  gene expression profiling  GNG4 gene  human  human cell  human tissue  lymphocyte differentiation  priority journal  protein expression  regulatory T lymphocyte  RNA sequencing  sequence analysis  T lymphocyte  T lymphocyte activation  thymic medulla  thymocyte  thymus  XCL1 gene  
An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:  Zhao P.;  Sun X.;  Chaggan C.;  Liao Z.;  Wong K.I.;  He F.;  Singh S.;  Loomba R.;  Karin M.;  Witztum J.L.;  Saltiel A.R.
收藏  |  浏览/下载：35/0  |  提交时间：2020/07/28
6,7 dihydro 4 hydroxy 3 (2' hydroxy 1,1' biphenyl 4 yl) 6 oxothieno[2,3 b]pyridine 5 carbonitrile  adenosine phosphate  caspase 3  caspase 6  caspase 7  cytochrome c  hydroxymethylglutaryl coenzyme A reductase kinase  matrix metalloproteinase  apoptosis  cytochrome  enzyme  enzyme activity  inhibition  protein  rodent  AMPK signaling  animal experiment  animal model  animal tissue  apoptosis  Article  C57BL 6 mouse  cell death  controlled study  drug mechanism  enzyme activation  enzyme activity  enzyme inhibition  enzyme phosphorylation  enzyme repression  gene knockout  human  human cell  human tissue  liver cell  liver fibrosis  liver injury  male  mouse  nonalcoholic steatohepatitis  nonhuman  priority journal  protein cleavage  protein secretion