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Generation of nonhuman primate retinitis pigmentosa model by in situ knockout of RHO in rhesus macaque retina 期刊论文
Science Bulletin, 2021, 卷号: 66, 期号: 4
作者:  Li S.;  Hu Y.;  Li Y.;  Hu M.;  Wang W.;  Ma Y.;  Cai Y.;  Wei M.;  Yao Y.;  Wang Y.;  Dong K.;  Gu Y.;  Zhao H.;  Bao J.;  Qiu Z.;  Zhang M.;  Hu X.;  Xue T.
收藏  |  浏览/下载:56/0  |  提交时间:2021/09/01
Disease model  Gene editing  Nonhuman primate model  Retinitis pigmentosa  Rhodopsin  SaCas9  
Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  Suomivuori C.-M.;  Latorraca N.R.;  Wingler L.M.;  Eismann S.;  King M.C.;  Kleinhenz A.L.W.;  Skiba M.A.;  Staus D.P.;  Kruse A.C.;  Lefkowitz R.J.;  Dror R.O.
收藏  |  浏览/下载:26/0  |  提交时间:2020/07/28
angiotensin 1 receptor  beta arrestin 1  beta arrestin 2  G protein coupled receptor  rhodopsin  chemical binding  design method  ligand  molecular analysis  protein  signaling  allosterism  Article  carboxy terminal sequence  conformational transition  controlled study  crystal structure  human  ligand binding  molecular dynamics  priority journal  protein conformation  signal transduction  structural model