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Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:  Freeman S.A.;  Uderhardt S.;  Saric A.;  Collins R.F.;  Buckley C.M.;  Mylvaganam S.;  Boroumand P.;  Plumb J.;  Germain R.N.;  Ren D.;  Grinstein S.
收藏  |  浏览/下载：25/0  |  提交时间：2020/07/28
cation channel  chemokine receptor CCR2  chloride  colony stimulating factor 1  epidermal growth factor  epidermal growth factor receptor  lipid  sialoadhesin  sodium ion  tetrandrine  two pore channel  unclassified drug  calcium channel  lipid  Mcoln1 protein, mouse  sodium  TPCN1 protein, mouse  TPCN2 protein, mouse  transient receptor potential channel  cation  homeostasis  immune system  protein  recycling  animal experiment  Article  bone marrow derived macrophage  cell vacuole  cell volume  channel gating  chloride transport  concentration (parameter)  controlled study  endocytosis  extracellular fluid  extracellular space  homeostasis  human  human cell  human tissue  immunosurveillance  in vitro study  internalization  ion current  knockout mouse  macropinocytosis  mouse  nonhuman  priority journal  protein stability  RNA interference  sodium transport  tonoplast  animal  cell organelle  endosome  genetics  immunology  ion transport  macrophage  metabolism  osmosis  physiology  pinocytosis  Animals  Calcium Channels  Endosomes  Immunologic Surveillance  Ion Transport  Lipids  Macrophages  Mice  Mice, Knockout  Organelles  Osmosis  Pinocytosis  Sodium  Transient Receptor Potential Channels  Vacuoles  
Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  Yu J.;  Gimenez L.E.;  Hernandez C.C.;  Wu Y.;  Wein A.H.;  Han G.W.;  McClary K.;  Mittal S.R.;  Burdsall K.;  Stauch B.;  Wu L.;  Stevens S.N.;  Peisley A.;  Williams S.Y.;  Chen V.;  Millhauser G.L.;  Zhao S.;  Cone R.D.;  Stevens R.C.
收藏  |  浏览/下载：30/0  |  提交时间：2020/07/28
alpha intermedin  calcium ion  cyclic AMP  G protein coupled receptor  heterotrimeric guanine nucleotide binding protein  inwardly rectifying potassium channel  inwardly rectifying potassium channel subunit Kir7.1  melanocortin 4 receptor  n acetyl alpha intermedin[4-10]cyclo[4 norleucine 5 aspartic acid 7 [3 (2 naphthyl)alanine] 10 lysinamide]  unclassified drug  calcium  G protein coupled receptor  intermedin  inwardly rectifying potassium channel  Kir7.1 channel  ligand  melanocortin 4 receptor  n acetyl alpha intermedin[4-10]cyclo[4 norleucine 5 aspartic acid 7 [3 (2 naphthyl)alanine] 10 lysinamide]  protein binding  calcium  chemical binding  homeostasis  hormone  ligand  obesity  peptide  protein  Article  binding affinity  complex formation  crystallization  drug structure  extracellular calcium  human  ligand binding  priority journal  protein structure  receptor blocking  signal transduction  chemistry  genetics  mutation  protein multimerization  protein secondary structure  X ray crystallography  Calcium  Crystallography, X-Ray  Cyclic AMP  Humans  Ligands  Melanocyte-Stimulating Hormones  Mutation  Potassium Channels, Inwardly Rectifying  Protein Binding  Protein Multimerization  Protein Structure, Secondary  Receptor, Melanocortin, Type 4  Receptors, G-Protein-Coupled  Signal Transduction