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Structural basis of Gs and Gi recognition by the human glucagon receptor
期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:
Qiao A.
;
Han S.
;
Li X.
;
Li Z.
;
Zhao P.
;
Dai A.
;
Chang R.
;
Tai L.
;
Tan Q.
;
Chu X.
;
Ma L.
;
Thorsen T.S.
;
Reedtz-Runge S.
;
Yang D.
;
Wang M.-W.
;
Sexton P.M.
;
Wootten D.
;
Sun F.
;
Zhao Q.
;
Wu B.
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2020/07/28
cyclic AMP
glucagon
glucagon receptor
inhibitory guanine nucleotide binding protein
stimulatory guanine nucleotide binding protein
glucagon receptor
inhibitory guanine nucleotide binding protein
protein binding
stimulatory guanine nucleotide binding protein
chemical binding
enzyme activity
gene expression
mutagenicity
protein
alpha helix
Article
binding affinity
carboxy terminal sequence
conformational transition
cryoelectron microscopy
human
molecular recognition
mutagenesis
priority journal
protein binding
protein function
protein protein interaction
protein structure
signal transduction
binding site
chemistry
metabolism
molecular model
protein conformation
ultrastructure
Binding Sites
Cryoelectron Microscopy
Glucagon
GTP-Binding Protein alpha Subunits, Gi-Go
GTP-Binding Protein alpha Subunits, Gs
Humans
Models, Molecular
Protein Binding
Protein Conformation
Protein Conformation, alpha-Helical
Receptors, Glucagon
Signal Transduction
Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding
期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:
Yu J.
;
Gimenez L.E.
;
Hernandez C.C.
;
Wu Y.
;
Wein A.H.
;
Han G.W.
;
McClary K.
;
Mittal S.R.
;
Burdsall K.
;
Stauch B.
;
Wu L.
;
Stevens S.N.
;
Peisley A.
;
Williams S.Y.
;
Chen V.
;
Millhauser G.L.
;
Zhao S.
;
Cone R.D.
;
Stevens R.C.
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/07/28
alpha intermedin
calcium ion
cyclic AMP
G protein coupled receptor
heterotrimeric guanine nucleotide binding protein
inwardly rectifying potassium channel
inwardly rectifying potassium channel subunit Kir7.1
melanocortin 4 receptor
n acetyl alpha intermedin[4-10]cyclo[4 norleucine 5 aspartic acid 7 [3 (2 naphthyl)alanine] 10 lysinamide]
unclassified drug
calcium
G protein coupled receptor
intermedin
inwardly rectifying potassium channel
Kir7.1 channel
ligand
melanocortin 4 receptor
n acetyl alpha intermedin[4-10]cyclo[4 norleucine 5 aspartic acid 7 [3 (2 naphthyl)alanine] 10 lysinamide]
protein binding
calcium
chemical binding
homeostasis
hormone
ligand
obesity
peptide
protein
Article
binding affinity
complex formation
crystallization
drug structure
extracellular calcium
human
ligand binding
priority journal
protein structure
receptor blocking
signal transduction
chemistry
genetics
mutation
protein multimerization
protein secondary structure
X ray crystallography
Calcium
Crystallography, X-Ray
Cyclic AMP
Humans
Ligands
Melanocyte-Stimulating Hormones
Mutation
Potassium Channels, Inwardly Rectifying
Protein Binding
Protein Multimerization
Protein Structure, Secondary
Receptor, Melanocortin, Type 4
Receptors, G-Protein-Coupled
Signal Transduction