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Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  Wingler L.M.;  Skiba M.A.;  McMahon C.;  Staus D.P.;  Kleinhenz A.L.W.;  Suomivuori C.-M.;  Latorraca N.R.;  Dror R.O.;  Lefkowitz R.J.;  Kruse A.C.
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/28
angiotensin 1 receptor  beta arrestin  G protein coupled receptor  biochemistry  crystal chemistry  crystal structure  physiological response  protein  signaling  allosterism  alpha helix  amino terminal sequence  Article  binding affinity  binding site  carboxy terminal sequence  conformational transition  crystallization  hydrogen bond  molecular dynamics  priority journal  protein binding  protein conformation  protein protein interaction  protein stability  signal transduction  thermostability  
Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  Suomivuori C.-M.;  Latorraca N.R.;  Wingler L.M.;  Eismann S.;  King M.C.;  Kleinhenz A.L.W.;  Skiba M.A.;  Staus D.P.;  Kruse A.C.;  Lefkowitz R.J.;  Dror R.O.
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/28
angiotensin 1 receptor  beta arrestin 1  beta arrestin 2  G protein coupled receptor  rhodopsin  chemical binding  design method  ligand  molecular analysis  protein  signaling  allosterism  Article  carboxy terminal sequence  conformational transition  controlled study  crystal structure  human  ligand binding  molecular dynamics  priority journal  protein conformation  signal transduction  structural model  
Structure of V-ATPase from the mammalian brain 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者:  Abbas Y.M.;  Wu D.;  Bueler S.A.;  Robinson C.V.;  Rubinstein J.L.
收藏  |  浏览/下载:32/0  |  提交时间:2020/07/28
adenosine triphosphatase  neurotransmitter  proton  renin  unclassified drug  vacuolar type adenosine triphosphatase  Atp6ap1 protein, rat  ATP6AP2 protein, rat  bacterial protein  biological marker  cell surface receptor  proton transporting adenosine triphosphate synthase  blood  brain  catalysis  catalyst  enzyme  enzyme activity  membrane  protein  Article  axon  blood pressure regulation  brain tissue  catalysis  chemical structure  cryoelectron microscopy  electrolyte balance  electron microscopy  human  hydrolysis  Legionella pneumophila  molecular docking  nerve cell  neurotransmitter uptake  nonhuman  priority journal  protein structure  signal transduction  Wnt signaling  yeast  animal  biocatalysis  brain  cell membrane  chemical model  chemistry  enzymology  protein domain  rat  renin angiotensin aldosterone system  Legionella pneumophila  Mammalia  Rattus  Animals  Bacterial Proteins  Biocatalysis  Biomarkers  Brain  Cell Membrane  Cryoelectron Microscopy  Models, Chemical  Protein Domains  Rats  Receptors, Cell Surface  Renin-Angiotensin System  Vacuolar Proton-Translocating ATPases  Wnt Signaling Pathway