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BRET-based effector membrane translocation assay monitors GPCR-promoted and endocytosis-mediated Gqactivation at early endosomes 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 20
作者:  Wright S.C.;  Lukasheva V.;  Gouill C.L.;  Kobayashi H.;  Breton B.;  Mailhot-Larouche S.;  Blondel-Tepaz E.;  Vieira N.A.;  Costa-Neto C.;  Héroux M.;  Lambert N.A.;  Parreiras-E-Silva L.T.;  Bouvier M.
收藏  |  浏览/下载：24/0  |  提交时间：2021/11/25
Recurrent high-impact mutations at cognate structural positions in class A G protein-coupled receptors expressed in tumors 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 51
作者:  Huh E.;  Gallion J.;  Agosto M.A.;  Wright S.J.;  Wensel T.G.;  Lichtarge O.
收藏  |  浏览/下载：14/0  |  提交时间：2022/02/22
aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2-mediated SphK1-S1PR1-Akt signaling axis 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 49
作者:  Molinar-Inglis O.;  Birch C.A.;  Nicholas D.;  Orduña-Castillo L.;  Cisneros-Aguirre M.;  Patwardhan A.;  Chen B.;  Grimsey N.J.;  Coronel L.J.;  Lin H.;  Gomez Menzies P.K.;  Lawson M.A.;  Patel H.H.;  Trejo J.
收藏  |  浏览/下载：29/0  |  提交时间：2022/02/22
High-mass MALDI-MS unravels ligand-mediated G protein-coupling selectivity to GPCRs 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 31
作者:  Wu N.;  Olechwier A.M.;  Brunner C.;  Edwards P.C.;  Tsai C.-J.;  Tate C.G.;  Schertler G.F.X.;  Schneider G.;  Deupi X.;  Zenobi R.;  Ma P.
收藏  |  浏览/下载：17/0  |  提交时间：2022/02/22
Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  Wingler L.M.;  Skiba M.A.;  McMahon C.;  Staus D.P.;  Kleinhenz A.L.W.;  Suomivuori C.-M.;  Latorraca N.R.;  Dror R.O.;  Lefkowitz R.J.;  Kruse A.C.
收藏  |  浏览/下载：25/0  |  提交时间：2020/07/28
angiotensin 1 receptor  beta arrestin  G protein coupled receptor  biochemistry  crystal chemistry  crystal structure  physiological response  protein  signaling  allosterism  alpha helix  amino terminal sequence  Article  binding affinity  binding site  carboxy terminal sequence  conformational transition  crystallization  hydrogen bond  molecular dynamics  priority journal  protein binding  protein conformation  protein protein interaction  protein stability  signal transduction  thermostability  
Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  Suomivuori C.-M.;  Latorraca N.R.;  Wingler L.M.;  Eismann S.;  King M.C.;  Kleinhenz A.L.W.;  Skiba M.A.;  Staus D.P.;  Kruse A.C.;  Lefkowitz R.J.;  Dror R.O.
收藏  |  浏览/下载：17/0  |  提交时间：2020/07/28
angiotensin 1 receptor  beta arrestin 1  beta arrestin 2  G protein coupled receptor  rhodopsin  chemical binding  design method  ligand  molecular analysis  protein  signaling  allosterism  Article  carboxy terminal sequence  conformational transition  controlled study  crystal structure  human  ligand binding  molecular dynamics  priority journal  protein conformation  signal transduction  structural model  
Mechanism of β-arrestin recruitment by the μ-opioid G protein-coupled receptor 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2020, 卷号: 117, 期号: 28
作者:  Mafi A.;  Kim S.-K.;  Goddard W.A.;  III
收藏  |  浏览/下载：23/0  |  提交时间：2021/01/06
PGE(2) Inhibits IL-10 Production via EP2-Mediated beta-Arrestin Signaling in Neuroinflammatory Condition 期刊论文
MOLECULAR NEUROBIOLOGY, 2015, 卷号: 52, 期号: 1, 页码: 587-600
作者:  Chu, Chun-Hsien;  Chen, Shih-Heng;  Wang, Qingshan;  Langenbach, Robert;  Li, Hong;  Zeldin, Darryl;  Chen, Shiou-Lan;  Wang, Shijun;  Gao, Huiming;  Lu, Ru-Band;  Hong, Jau-Shyong
收藏  |  浏览/下载：42/0  |  提交时间：2019/05/04