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Efficacy of Nirmatrelvir-Ritonavir versus Azvudine for COVID-19 Treatment in Tibet: A Retrospective Study 期刊论文
INFECTION AND DRUG RESISTANCE, 2023, 卷号: 16
作者:  Zhao, Xiang;  Cheng, Yuan;  Zhang, Meng;  Qianda, Bianba;  Zhouma, Baima;  Yangzhen, Bianba;  Zheng, Yao;  Zhang, Shuo;  Zhao, Huiying
收藏  |  浏览/下载：1/0  |  提交时间：2024/03/01
nirmatrelvir-ritonavir  azvudine  COVID-19  clinical outcome  high altitude  
Science academies publish statements on primary concerns for international action ahead of the G7 summit 科技资讯
2022
收藏  |  浏览/下载：9/0  |  提交时间：2022/06/01
Review on Meteorological and Air Quality Factors Affecting the COVID-19 Pandemic 科技报告
, 2021
作者:  [unavailable]
Adobe PDF(1972Kb)  |  收藏  |  浏览/下载：23/2  |  提交时间：2021/11/24
Drugs used to treat HIV and flu can have detrimental impact on crops 科技资讯
2021
收藏  |  浏览/下载：1/0  |  提交时间：2021/01/29
The Sw5a gene confers resistance to ToLCNDV and triggers an HR response after direct AC4 effector recognition 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 33
作者:  Sharma N.;  Sahu P.P.;  Prasad A.;  Muthamilarasan M.;  Waseem M.;  Khan Y.;  Thakur J.K.;  Chakraborty S.;  Prasad M.
收藏  |  浏览/下载：49/0  |  提交时间：2021/11/25
miR-122-based therapies select for three distinct resistance mechanisms based on alterations in RNA structure 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 33
作者:  Chahal J.;  Gebert L.F.R.;  Camargo C.;  MacRae I.J.;  Sagan S.M.
收藏  |  浏览/下载：10/0  |  提交时间：2021/11/25
Structural basis for strand-transfer inhibitor binding to HIV intasomes 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  Passos D.O.;  Li M.;  Jóźwik I.K.;  Zhao X.Z.;  Santos-Martins D.;  Yang R.;  Smith S.J.;  Jeon Y.;  Forli S.;  Hughes S.H.;  Burke T.R.;  Jr.;  Craigie R.;  Lyumkis D.
收藏  |  浏览/下载：16/0  |  提交时间：2020/07/28
bictegravir  nucleoprotein  protein intasome  unclassified drug  viral protein  bictegravir  fused heterocyclic rings  integrase  integrase inhibitor  multiprotein complex  naphthyridine derivative  nucleoprotein  biochemistry  chemical binding  human immunodeficiency virus  inhibitor  protein  ultrastructure  amino terminal sequence  Article  carboxy terminal sequence  catalysis  cryoelectron microscopy  drug design  drug efficacy  drug protein binding  drug resistance  drug structure  enzyme active site  human  Human immunodeficiency virus infection  nonhuman  priority journal  protein purification  protein structure  antiviral resistance  chemistry  drug effect  genetics  Human immunodeficiency virus  virus DNA cell DNA interaction  Cryoelectron Microscopy  Drug Design  Drug Resistance, Viral  Heterocyclic Compounds, 4 or More Rings  HIV  HIV Integrase  HIV Integrase Inhibitors  Humans  Multiprotein Complexes  Naphthyridines  Nucleoproteins  Virus Integration  
Structural basis of second-generation HIV integrase inhibitor action and viral resistance 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  Cook N.J.;  Li W.;  Berta D.;  Badaoui M.;  Ballandras-Colas A.;  Nans A.;  Kotecha A.;  Rosta E.;  Engelman A.N.;  Cherepanov P.
收藏  |  浏览/下载：26/0  |  提交时间：2020/07/28
bictegravir  dolutegravir  lens epithelium derived growth factor  magnesium ion  bictegravir  dolutegravir  fused heterocyclic rings  glutamine  glycine  histidine  integrase  integrase inhibitor  magnesium  serine  acquired immune deficiency syndrome  amino acid  drug  human immunodeficiency virus  inhibitor  protein  ultrastructure  virus  amino acid substitution  amino terminal sequence  Article  carboxy terminal sequence  cryoelectron microscopy  DNA binding  drug design  drug protein binding  drug structure  enzyme active site  gene mutation  Human immunodeficiency virus 1  in vitro study  molecular dynamics  molecular stability  nonhuman  pharmacophore  polarization  priority journal  protonation  virus resistance  antiviral resistance  chemistry  genetics  human  mutation  procedures  single molecule imaging  Amino Acid Substitution  Catalytic Domain  Cryoelectron Microscopy  Drug Resistance, Viral  Glutamine  Glycine  Heterocyclic Compounds, 3-Ring  Heterocyclic Compounds, 4 or More Rings  Histidine  HIV Integrase  HIV Integrase Inhibitors  Humans  Magnesium  Mutation  Serine  Single Molecule Imaging  
Ferrocene derivatives as anti-infective agents 期刊论文
COORDINATION CHEMISTRY REVIEWS, 2019, 卷号: 396, 页码: 22-48
作者:  Ludwig, Beatrice S.;  Correia, Joao D. G.;  Kuehn, Fritz E.
收藏  |  浏览/下载：29/0  |  提交时间：2019/11/07
Southern sea otter (Enhydra lutris nereis) population biology at Big Sur and Monterey, California --Investigating the consequences of resource abundance and anthropogenic stressors for sea otter recovery 科技报告
报告编号: 70202708, 页数: 244, 2019
作者:  Tinker, M. Tim;  Tomoleoni, Joseph A. jtomoleoni@usgs.gov;  Weitzman, Benjamin P.;  Staedler, Michelle;  Jessup, Dave;  Murray, Michael J.;  Miller, Melissa;  Burgess, Tristan;  Bowen, Lizabeth lbowen@usgs.gov;  Miles, A. Keith keith_miles@usgs.gov;  Thometz, Nicole;  Tarjan, Lily;  Golson, Emily;  Batac, Francesca;  Dodd, Erin;  Berberich, Eva;  Kunz, Jessica;  Bentall, Gena;  Fujii, Jessica;  Nicholson, Teri;  Newsome, Seth;  Melli, Ann;  LaRoche, Nicole;  MacCormick, Holly;  Johnson, Andy;  Henkel, Laird;  Kreuder-Johnson, Chris;  Conrad, Pat
Adobe PDF(15940Kb)  |  收藏  |  浏览/下载：99/20  |  提交时间：2019/11/06