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Partitioning of cancer therapeutics in nuclear condensates 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Klein I.A.;  Boija A.;  Afeyan L.K.;  Hawken S.W.;  Fan M.;  Dall'Agnese A.;  Oksuz O.;  Henninger J.E.;  Shrinivas K.;  Sabari B.R.;  Sagi I.;  Clark V.E.;  Platt J.M.;  Kar M.;  McCall P.M.;  Zamudio A.V.;  Manteiga J.C.;  Coffey E.L.;  Li C.H.;  Hannett N.M.;  Guo Y.E.;  Decker T.-M.;  Lee T.I.;  Zhang T.;  Weng J.-K.;  Taatjes D.J.;  Chakraborty A.;  Sharp P.A.;  Chang Y.T.;  Hyman A.A.;  Gray N.S.;  Young R.A.
收藏  |  浏览/下载：33/0  |  提交时间：2020/07/28
cancer  condensate  disease  drug  physicochemical property  protein  tumor  antineoplastic agent  BRD4 protein, human  cell cycle protein  green fluorescent protein  heterochromatin-specific nonhistone chromosomal protein HP-1  MED1 protein, human  nonhistone protein  nuclear protein  nucleophosmin  peroxisome proliferator activated receptor binding protein  recombinant protein  serine arginine rich splicing factor  SRSF2 protein, human  transcription factor  cell nucleus  drug resistance  genetics  human  metabolism  neoplasm  Antineoplastic Agents  Cell Cycle Proteins  Cell Nucleus  Chromosomal Proteins, Non-Histone  Drug Resistance, Neoplasm  Green Fluorescent Proteins  Humans  Mediator Complex Subunit 1  Neoplasms  Nuclear Proteins  Recombinant Proteins  Serine-Arginine Splicing Factors  Transcription Factors  
Structural basis of second-generation HIV integrase inhibitor action and viral resistance 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  Cook N.J.;  Li W.;  Berta D.;  Badaoui M.;  Ballandras-Colas A.;  Nans A.;  Kotecha A.;  Rosta E.;  Engelman A.N.;  Cherepanov P.
收藏  |  浏览/下载：28/0  |  提交时间：2020/07/28
bictegravir  dolutegravir  lens epithelium derived growth factor  magnesium ion  bictegravir  dolutegravir  fused heterocyclic rings  glutamine  glycine  histidine  integrase  integrase inhibitor  magnesium  serine  acquired immune deficiency syndrome  amino acid  drug  human immunodeficiency virus  inhibitor  protein  ultrastructure  virus  amino acid substitution  amino terminal sequence  Article  carboxy terminal sequence  cryoelectron microscopy  DNA binding  drug design  drug protein binding  drug structure  enzyme active site  gene mutation  Human immunodeficiency virus 1  in vitro study  molecular dynamics  molecular stability  nonhuman  pharmacophore  polarization  priority journal  protonation  virus resistance  antiviral resistance  chemistry  genetics  human  mutation  procedures  single molecule imaging  Amino Acid Substitution  Catalytic Domain  Cryoelectron Microscopy  Drug Resistance, Viral  Glutamine  Glycine  Heterocyclic Compounds, 3-Ring  Heterocyclic Compounds, 4 or More Rings  Histidine  HIV Integrase  HIV Integrase Inhibitors  Humans  Magnesium  Mutation  Serine  Single Molecule Imaging  
Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1 期刊论文
, 2020, 卷号: 367, 期号: 6474
作者:  Yoon I.;  Nam M.;  Kim H.K.;  Moon H.-S.;  Kim S.;  Jang J.;  Song J.A.;  Jeong S.J.;  Kim S.B.;  Cho S.;  Kim Y.;  Lee J.;  Yang W.S.;  Yoo H.C.;  Kim K.;  Kim M.-S.;  Yang A.;  Cho K.;  Park H.-S.;  Hwang G.-S.;  Hwang K.Y.;  Han J.M.;  Kim J.H.;  Kim S.
收藏  |  浏览/下载：29/0  |  提交时间：2020/07/28
glucose  leucine  leucine transfer RNA ligase  leucyl tRNA synthetase 1  mammalian target of rapamycin complex 1  S6 kinase  serine threonine protein kinase ULK1  unclassified drug  glucose  leucine  leucine transfer RNA ligase  mammalian target of rapamycin complex 1  monomeric guanine nucleotide binding protein  serine threonine protein kinase ULK1  catabolism  cell  enzyme  enzyme activity  glucose  metabolism  protein  survival  amino acid metabolism  animal cell  Article  binding affinity  cell survival  circular dichroism  controlled study  embryo  energy yield  enzyme activity  enzyme phosphorylation  enzyme regulation  fluorescence resonance energy transfer  human  human cell  mouse  nonhuman  priority journal  protein binding  protein domain  protein motif  protein processing  protein synthesis  signal transduction  starvation  animal  energy metabolism  fibroblast  genetics  HEK293 cell line  HeLa cell line  lysosome  metabolism  phosphorylation  Animals  Autophagy-Related Protein-1 Homolog  Energy Metabolism  Fibroblasts  Glucose  HEK293 Cells  HeLa Cells  Humans  Leucine  Leucine-tRNA Ligase  Lysosomes  Mechanistic Target of Rapamycin Complex 1  Mice  Monomeric GTP-Binding Proteins  Phosphorylation  Signal Transduction