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DOI10.1016/j.jtherbio.2019.01.011
A controlled heat stress during late gestation affects thermoregulation, productive performance, and metabolite profiles of primiparous sow
He, Jianwen1; Zheng, Weijiang1,2; Lu, Mingzhou3; Yang, Xiaojing4; Xue, Yongqiang1; Yao, Wen1,2,4
发表日期2019
ISSN0306-4565
卷号81页码:33-40
英文摘要

Heat stress (HS) alters metabolic parameters and reduces productive performance in lactating sows. However, the impact of HS on metabolomic profiles of sows during late gestation is not fully understood. We present here, a study investigating the productive performance and metabolic responses in sows when exposed to HS during late gestation. Twelve first-parity Landrace x Large White Fl sows were randomly assigned into two environmental treatments including the thennoneutral (TN) (18-22 degrees C; n = 6) and HS (28-32 degrees C; n = 6) conditions from 85 d of gestation until farrowing. Rectal temperature (RT), respiration rates (RR), and surface temperature (ST) were measured every 4 h from 0800 h to 2000 h during the 2nd week. Farrowing and litter Data, as well as duration of eating, were monitored to assess sows' productive performance. Blood biochemical parameters and urinary metabolomic profiles were measured on d107 of gestation to analyze the host metabolic responses. Our results show that HS increased RT, RR, and ST (P < 0.0001). Duration of parturition was prolonged during the delivery in HS group (P < 0.05). Piglet body weight (SW) at d 10 and weaning were reduced by 18% and 17% respectively due to maternal HS (P < 0.001). Duration of eating increased as a result of HS (P < 0.001), consistent with the significant changes observed in serum ghrelin (P < 0.05). Moreover, serum ACTH, cortisol, insulin, creatinine, and BUN saw increase as well (P < 0.05). Plasma NEFA were elevated by HS (P < 0.001). Additionally, HS elevated (VIP > 1, log(2) fold change > 0.585, and P < 0.05) the relative concentrations of 5-aminovaleric acid, beta-alanine, cysteine, isoleucine, glyceric acid, erythronic acid, mannitol, erythritol, 2-methyl-1,3-butanediol, and pantothenic acid in urine. These ten metabolites mainly affected the pantothenate and CoA biosynthesis, beta-alanine metabolism, and glycerolipid metabolism in pregnant sows. In summary, our study suggests that the controlled HS during late gestation elevates thermal responses, reduces productive performance, and more importantly, enhances the catabolism of lipid and protein of first-parity pregnant sow.


WOS研究方向Life Sciences & Biomedicine - Other Topics ; Zoology
来源期刊JOURNAL OF THERMAL BIOLOGY
文献类型期刊论文
条目标识符http://gcip.llas.ac.cn/handle/2XKMVOVA/95906
作者单位1.Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China;
2.Nanjing Agr Univ, Natl Expt Teaching Ctr Anim Sci, Nanjing 210095, Jiangsu, Peoples R China;
3.Nanjing Agr Univ, Lab Modern Facil Agr Technol & Equipment Engn Jia, Coll Engn, Nanjing 210031, Jiangsu, Peoples R China;
4.Nanjing Agr Univ, Minist Agr & Rural Affairs Peoples Republ China, Key Lab Anim Physiol & Biochem, Nanjing 210095, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714
He, Jianwen,Zheng, Weijiang,Lu, Mingzhou,et al. A controlled heat stress during late gestation affects thermoregulation, productive performance, and metabolite profiles of primiparous sow[J],2019,81:33-40.
APA He, Jianwen,Zheng, Weijiang,Lu, Mingzhou,Yang, Xiaojing,Xue, Yongqiang,&Yao, Wen.(2019).A controlled heat stress during late gestation affects thermoregulation, productive performance, and metabolite profiles of primiparous sow.JOURNAL OF THERMAL BIOLOGY,81,33-40.
MLA He, Jianwen,et al."A controlled heat stress during late gestation affects thermoregulation, productive performance, and metabolite profiles of primiparous sow".JOURNAL OF THERMAL BIOLOGY 81(2019):33-40.
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