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DOI | 10.5578/mb.67680 |
A Native Mixed Plasmodium falciparum and Plasmodium vivax Malaria Case Molecularly Proven After 22 Years in Manisa, Turkey | |
Ok, Ulgen Zeki1; Cavus, Ibrahim1; Sidal, Ugur2; Lmoncu, Emin3; Ozbilgin, Ahmet1 | |
发表日期 | 2019 |
ISSN | 0374-9096 |
卷号 | 53期号:2页码:239-244 |
英文摘要 | Plasmodium falciparum malaria causes about 450.000 deaths every year, mostly in children around the world. The infection is seen in cases coming from abroad and may lead to deaths in Turkey. Many native P.falciparum malaria cases and deaths due to this infection were observed in Turkey during mid 1900's when malaria was epidemic. But only two native cases were reported in the last 50 years, both from Manisa. First case was a one-year old baby who has come to Manisa from Urfa with his family and has never been abroad. He has diagnosed with Plasmodium vivax malaria and treated with chloroquine and primaquine. A previously obtained thin blood film was examined and characteristic P.falciparum rings in red blood cells were observed and the case was published together with photographs as probable P.falciparum and P.vivax mixed infection. After this case, microscopists working in Malaria Control Unit of Manisa were informed about the differentiation of malaria species in thin blood samples. Soon afterward, another case who have never been abroad before were also diagnosed with P.falciparum and P.vivax mixed infection and this case was also published with photographs taken from thin blood samples. As molecular diagnostic methods were not improved and widespread in those years, it could not be applied in both cases. A Giemsa stained thin blood sample of the baby case was incidentally found 22 years afterwards and with the aim of molecular diagnosis, the blood sample on the slide previously processed for DNA isolation, then analysed with "FTD Malaria Differentiation (Fast Track Diagnostics, Luxembourg)" multiplex kit with real-time polymerase chain reaction by using probes special for P.falciparum, P.ovale, P.malariae, P.vivax species. DNA's belonging to P.falciparum and P.vivax were found to be positive, the case is molecularly proved to have P.falciparum and P.vivax mixed infection. This case indicated that Turkey is convenient for the expansion of P.falciparum malaria in terms of the climate and vectors and suggested that the potential danger may increase with the effects of global warming, wars and migrations and may jump to Europe over Turkey. The case which molecularly proved the existence of native P.falciparum malaria in the near future in Turkey, was presented to draw attention to the danger of this infection for Turkey and Europe. |
WOS研究方向 | Microbiology |
来源期刊 | MIKROBIYOLOJI BULTENI
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文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/95434 |
作者单位 | 1.Celal Bayar Univ, Dept Med Parasitol, Fac Med, Manisa, Turkey; 2.Celal Bayar Univ, Dept Biol, Fac Sci & Arts, Manisa, Turkey; 3.Celal Bayar Univ, Sch Hlth Serv, Manisa, Turkey |
推荐引用方式 GB/T 7714 | Ok, Ulgen Zeki,Cavus, Ibrahim,Sidal, Ugur,et al. A Native Mixed Plasmodium falciparum and Plasmodium vivax Malaria Case Molecularly Proven After 22 Years in Manisa, Turkey[J],2019,53(2):239-244. |
APA | Ok, Ulgen Zeki,Cavus, Ibrahim,Sidal, Ugur,Lmoncu, Emin,&Ozbilgin, Ahmet.(2019).A Native Mixed Plasmodium falciparum and Plasmodium vivax Malaria Case Molecularly Proven After 22 Years in Manisa, Turkey.MIKROBIYOLOJI BULTENI,53(2),239-244. |
MLA | Ok, Ulgen Zeki,et al."A Native Mixed Plasmodium falciparum and Plasmodium vivax Malaria Case Molecularly Proven After 22 Years in Manisa, Turkey".MIKROBIYOLOJI BULTENI 53.2(2019):239-244. |
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