Climate Change Data Portal
DOI | 10.1111/jnc.14630 |
Chronic over-expression of ubiquitin impairs learning, reduces synaptic plasticity, and enhances GRIA receptor turnover in mice | |
Vaden, Jada H.1; Tian, Tina1; Golf, Samantha1,2; McLean, John W.1; Wilson, Julie A.1; Wilson, Scott M.1 | |
发表日期 | 2019 |
ISSN | 0022-3042 |
EISSN | 1471-4159 |
卷号 | 148期号:3页码:386-399 |
英文摘要 | Ubiquitin is an essential signaling protein that controls many different cellular processes. While cellular ubiquitin levels normally cycle between pools of free and conjugated ubiquitin, the balance of these ubiquitin pools can be shifted by exposure to a variety of cellular stresses. Altered ubiquitin pools are also observed in several neurological disorders, suggesting that imbalances in ubiquitin homeostasis may contribute to neuronal dysfunction. To examine the effects of increased ubiquitin levels on the mammalian nervous system, we generated transgenic mice that express ubiquitin under the control of the Thy1.2 promoter. While we did not detect global changes in levels of ubiquitin conjugates in the hippocampus, we found that increasing ubiquitin levels reduced AMPA (GRIA1-4) receptor expression without affecting the levels of NMDA (GRIN) or GABA(A) receptors. Ubiquitin over-expression also negatively impacted hippocampus-dependent learning and memory as well as baseline excitability and synaptic plasticity at hippocampal CA3-CA1 synapses. These changes occurred in a dose-dependent manner in that mice with the highest levels of ubiquitin over-expression had the greatest deficits in synaptic function and were the most impaired in the learning and memory tasks. As chronic elevation of ubiquitin expression in neurons is sufficient to cause changes in synaptic function and cognition, altered ubiquitin homeostasis may be an important contributor to the stress-induced changes observed in neurological disorders. |
WOS研究方向 | Biochemistry & Molecular Biology ; Neurosciences & Neurology |
来源期刊 | JOURNAL OF NEUROCHEMISTRY
![]() |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/92600 |
作者单位 | 1.Univ Alabama Birmingham, Dept Neurobiol, Evelyn F McKnight Brain Inst, Civitan Int Res Ctr, 1825 Univ Blvd,SHEL 914, Birmingham, AL 35294 USA; 2.Stanford Univ, Stanford Neurosci Grad Program, Stanford, CA 94305 USA |
推荐引用方式 GB/T 7714 | Vaden, Jada H.,Tian, Tina,Golf, Samantha,et al. Chronic over-expression of ubiquitin impairs learning, reduces synaptic plasticity, and enhances GRIA receptor turnover in mice[J],2019,148(3):386-399. |
APA | Vaden, Jada H.,Tian, Tina,Golf, Samantha,McLean, John W.,Wilson, Julie A.,&Wilson, Scott M..(2019).Chronic over-expression of ubiquitin impairs learning, reduces synaptic plasticity, and enhances GRIA receptor turnover in mice.JOURNAL OF NEUROCHEMISTRY,148(3),386-399. |
MLA | Vaden, Jada H.,et al."Chronic over-expression of ubiquitin impairs learning, reduces synaptic plasticity, and enhances GRIA receptor turnover in mice".JOURNAL OF NEUROCHEMISTRY 148.3(2019):386-399. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。