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This research analyzed the spatiotemporal patterns of drought in Xinjiang (northwestern China) between 1961 and 2015 using the standardized precipitation evapotranspiration index (SPEI). Furthermore, the correlations between Atlantic Multidecadal Oscillation (AMO)/El Nino-Southern Oscillation (ENSO) events and drought were explored. The results suggested an obvious trend toward aggravated drought, with a significant inflection point in 1997, after which the frequency of drought increased sharply. Spatially, the increase in drought occurred largely in southern and eastern Xinjiang, where occurrences of moderate and extreme drought have become more frequent during the last two decades, whereas northwestern Xinjiang and the Pamir Plateau showed wetting trends. Empirical orthogonal function analysis (EOF) of drought patterns showed a north-south antiphase and an east-west antiphase distribution. The positive (negative) phase of the AMO was related to increased (decreased) drought in Xinjiang, particularly after 1997. During a warm phase (El Nino), major droughts occurred over northern Xinjiang, but they lagged by 12 months. However, not all El Nino and La Nina events were responsible for drought events in northern Xinjiang during this period, and other drivers remain to be identified. This study suggests the possibility of AMO and ENSO links to drought in Xinjiang, but further analysis is needed to better understand such mechanisms.