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Today, the hydrological regime in East and South Asia is dominated by the monsoons, whilst central Asia is characterized as arid. Studies that have examined the onset of aridity and the intensification of the monsoons in Asia have generated significant debate, especially in respect to the timing of monsoon onset and how this relates to the potential causal mechanisms. The uplift of the Tibetan Plateau, the retreat of the Paratethys Sea, and the global cooling after the Eocene/Oligocene transition are all considered major drivers of Asian aridity and monsoonal intensification. However, little is known about each of these factor's contribution to the development of modern monsoon behaviour. Here, for the first time, we perform sensitivity simulations of a fully coupled ocean-atmosphere climate model (HadCM3) to investigate the effect of the Greenland and Antarctic ice-sheets formation, atmospheric carbon dioxide (CO2) variability, and Tibetan Plateau uplift on East Central Asian aridity and monsoon driven precipitation. We focus on three individual regions, the South Asian Monsoon, the East Asian Monsoon and the Arid East Central Asia and we present the annual precipitation cycle and the moisture availability over each region. Our results show that of the parameters investigated the primary control on Asian hydroclimate is the topography of the Tibetan Plateau. Furthermore, our results highlight that the significance of each forcing depends on the component of the hydrological region and factors studied, a factor that proxy interpretation need to take into consideration. (C) 2019 Elsevier B.V. All rights reserved.