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DOI10.1007/s00294-018-0852-6
Chromatin mobility upon DNA damage: state of the art and remaining questions
Zimmer, Christophe1,2,3; Fabre, Emmanuelle4,5
发表日期2019
ISSN0172-8083
EISSN1432-0983
卷号65期号:1页码:1-9
英文摘要

Chromosome organization and chromatin mobility are central to DNA metabolism. In particular, it has been recently shown by several labs that double strand breaks (DSBs) in yeast induce a change in chromatin mobility at the site of the damage. Intriguingly, DSB also induces a global mobility of the genome, at others, potentially undamaged positions. How mobility is regulated and what are the functional outcomes of these global changes in chromatin dynamics are, however, not yet fully understood. We present the current state of knowledge in light of the recent literature and discuss some perspectives opened by these discoveries towards genome stability.


WOS研究方向Genetics & Heredity
来源期刊CURRENT GENETICS
文献类型期刊论文
条目标识符http://gcip.llas.ac.cn/handle/2XKMVOVA/89811
作者单位1.Inst Pasteur, Unite Imagerie & Modelisat, 25 Rue Docteur Roux, F-75015 Paris, France;
2.CNRS, UMR 3691, Paris, France;
3.CNRS, IP, C3BI, USR 3756, Paris, France;
4.Hop St Louis, Inst Univ Hematol, Equipe Biol & Dynam Chromosomes, Paris, France;
5.Univ Paris Diderot, Sorbonne Paris Cite, IUH, INSERM,U944,CNRS,UMR 7212, Paris, France
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Zimmer, Christophe,Fabre, Emmanuelle. Chromatin mobility upon DNA damage: state of the art and remaining questions[J],2019,65(1):1-9.
APA Zimmer, Christophe,&Fabre, Emmanuelle.(2019).Chromatin mobility upon DNA damage: state of the art and remaining questions.CURRENT GENETICS,65(1),1-9.
MLA Zimmer, Christophe,et al."Chromatin mobility upon DNA damage: state of the art and remaining questions".CURRENT GENETICS 65.1(2019):1-9.
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