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| Studies of aerosols climatology and effects in relation to atmospheric aerosol research for GBP applications | |
| P.K. Umesha | |
| 项目主持机构 | Mysore University |
| 开始日期 | 2001 |
| 结束日期 | 2004 |
| 英文摘要 | The objective of this project is to develop a new approach for concentrating ultrafine particles for animal inhalation studies. The electrodynamic aerosol concentrator invented by Periasamy, Ensor, and Donovan (1995) uses an ac field quadrupole to deflect the particles to the center of a flowing gas stream between the electrodes. Experiments conducted earlier with monodisperse 14 µm oleic acid aerosols tagged with uranine dye and electrodynamic quadrupole demonstrated significant focusing. Two key questions are addressed in this research: (1) Can the performance be extended to sub 0.1 µm particles? (2) Can the device be scaled up to provide sufficient flow for laboratory studies?Three activities will be conducted for this study: additional literaturereview, theoretical analysis, and initial laboratory experiments. Three relevant but obscure papers from the Japanese literature have beenretrieved (Aoyama and Masuda, 1970; Masuda and Fujibayashi, 1970; Masuda, etal., 1972). The Japanese researchers used approximations to analyze the problemand performed experiments with millimeter size particles to verify the theory. A subcontract to perform theoretical analysis was issued to the University ofMinnesota to support a postdoctoral student. The theoretical analysis wascompleted, and a computer program and final report was submitted to ResearchTriangle Institute (Park, et al., 2000). The initial theoretical analysisindicates that focusing and concentrating on particles smaller than 0.1 Fm atatmospheric pressure may be difficult. However, availability of the computerprogram will allow evaluation of various quadrupole configurations and toidentify unstable operating conditions. Also, Dr. Park performed some limitedtests with submicron particles under low-pressure, which has provided someinsights with respect to electrode design. A series of experiments will be conducted to repeat the earlier ResearchTriangle Institute (RTI) experiments with the original apparatus. A series ofmonodisperse oleic acid aerosols tagged with uranine dye from 15 down to 1 Fm iscurrently being conducted using the dye image formed during a experimental runon a filter placed after the quadrupole section. The focusing rate will bequantified with fluorometric analysis from concentric rings of the filter. (Thefocusing rate is a measure of the fraction of particle migrating to the centerpoint.) These data will allow validation of the computer program that will beused to support design of a second-generation electrode system.The research expectation for this study is to develop a new approach for concentrating ultrafine particles to further research in the field of animal inhalation studies. Supplemental Keywords: pollution prevention, atmosphere, particulates, metals, sensitive population., RFA, Health, Scientific Discipline, Air, particulate matter, Virology, Environmental Chemistry, Health Risk Assessment, Epidemiology, Risk Assessments, Biochemistry, Atmospheric Sciences, ambient air quality, particle size, particulates, sensitive populations, cardiopulmonary responses, chemical characteristics, fine particles, human health effects, ambient air monitoring, electrodynamic quadrupole aerosol concentrator, pulmonary disease, susceptible populations, epidemelogy, particle exposure, environmental health effects, human exposure, chemical kinetics, particulate exposure, mortality, urban environment, aerosols, chemical speciation sampling Progress and Final Reports: 1999 Progress Report 2000 Progress Report 2001 2002 2003 2004 Final Main Center Abstract and Reports: R827354 Airborne PM - Rochester PM Center Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center). R827354C001 Characterization of the Chemical Composition of Atmospheric Ultrafine Particles R827354C002 Inflammatory Responses and Cardiovascular Risk Factors in Susceptible Populations R827354C003 Clinical Studies of Ultrafine Particle Exposure in Susceptible Human Subjects R827354C004 Animal Models: Dosimetry, and Pulmonary and Cardiovascular Events R827354C005 Ultrafine Particle Cell Interactions: Molecular Mechanisms Leading to Altered Gene Expression R827354C006 Development of an Electrodynamic Quadrupole Aerosol Concentrator R827354C007 Kinetics of Clearance and Relocation of Insoluble Ultrafine Iridium Particles From the Rat Lung Epithelium to Extrapulmonary Organs and Tissues (Pilot Project) R827354C008 Ultrafine Oil Aerosol Generation for Inhalation Studies |
| 英文关键词 | pollution prevention;atmosphere;particulates;metals;sensitive population. |
| 学科分类 | 08 - 地球科学 |
| 资助机构 | IN-DST |
| 项目经费 | 854000 |
| URL | http://www.nstmis-dst.org/EMR/EMR2001-02/ViewData.aspx?id=3&sub=Earth%20Sciences |
| 国家 | IN |
| 语种 | 英语 |
| 文献类型 | 项目 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/77050 |
| 推荐引用方式 GB/T 7714 | P.K. Umesha.Studies of aerosols climatology and effects in relation to atmospheric aerosol research for GBP applications.2001. |
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