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| MRI: Development of a New Instrument to Observe Isotopic Fluxes of Methane and Carbon Dioxide from Arctic Melt Regions, to Link Carbon Fluxes, Climate Feedbacks and Sea Level Rise | |
| 项目编号 | 0922596 |
| James Anderson | |
| 项目主持机构 | Harvard University |
| 开始日期 | 2009-08-01 |
| 结束日期 | 2011-07-31 |
| 英文摘要 | Project Narrative: Many glycoproteins which are potent antidotes, exhibit very important physiological functions but cannot be used as therapeutic treatments because they are quickly removed from the circulation or their ability to protect requires large doses if given i.m. The aim of this project is to butyrylcholinesterase as an aerosol in a pulmonary delivery device to that it deposits in the lung and forms a 'bioshield' and detoxifies inhaled indecticides poisons in the lung and prevernts them from reaching the blood and the neuromuscular junctions where they can quickly cause severe toxicity. |
| 英文关键词 | Acute;Aerosol Drug Therapy;aerosolized;Aerosols;Agarose Chromatography;Agriculture;Animals;Antibodies;Antidotes;Area;Atropine;Award;Binding (Molecular Function);Biological Availability;Biomanufacturing;bioscavenger;Bioshield;Biotechnology;Blood;Blood Circulation;Breathing;Businesses;Butyrylcholinesterase;carbamate insecticide;cell bank;Cell Line;Cells;Cessation of life;Chemicals;Chlorpyrifos;cholinergic;cholinergic synapse;Chronic;Deposition;Development;Devices;Diazinon;Disadvantaged;Dose;Drug Kinetics;efficacy testing;Enzymes;Ethics;Exhibits;experience;expression cloning;Feasibility Studies;Functional disorder;Genes;Glycoproteins;Grant;Human;immunogenic;immunogenicity;In Situ;Individual;Industry;Inhalation Exposure;Injection of therapeutic agent;innovation;Insecticides;Institutes;Killings;Lethal Dose 50;Liquid substance;Lung;Macaca;Maryland;Measures;Mediating;Medicine;meetings;Modeling;Monkeys;Morbidity - disease rate;Mus;National Institute of Neurological Disorders and Stroke;neuromuscular;Neuromuscular Junction;Neuropathy;neurotoxic;neurotoxicity;Neurotoxins;nonhuman primate;organophosphate poisoning;Organophosphates;Oximes;Paraoxon;Pattern;pesticide exposure;Pharmaceutical Preparations;Phase;Physiological;Plasma;Poisoning;Poisons;Polysaccharides;Powder dose form;prevent;Procainamide;Process;Production;Proteins;Protocols documentation;public health medicine (field);public health relevance;Radionuclide Imaging;Recombinant Proteins;Recombinants;Regimen;respiratory;response;Route;Safety;safety study;safety testing;Sampling;Scanning;Sepharose;Serum;Small Business Innovation Research Grant;stoichiometry;Structure of parenchyma of lung;Supportive care;Symptoms;System;Technetium 99m;Testing;Therapeutic;therapeutic protein;Time;Toxic effect;Translational Research;Universities;user-friendly;Veterinarians;Work;Writing |
| 学科分类 | 08 - 地球科学;0805 - 大气科学 |
| 资助机构 | US-NSF |
| 项目经费 | 1048994 |
| 项目类型 | Standard Grant |
| 国家 | US |
| 语种 | 英语 |
| 文献类型 | 项目 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/76304 |
| 推荐引用方式 GB/T 7714 | James Anderson.MRI: Development of a New Instrument to Observe Isotopic Fluxes of Methane and Carbon Dioxide from Arctic Melt Regions, to Link Carbon Fluxes, Climate Feedbacks and Sea Level Rise.2009. |
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