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| CHARACTERIZING AEROSOL DIRECT RADIATIVE EFFECTS IN CLEAR SKIES AND ABOVE CLOUDS, AND NEAR-CLOUD SPATIAL DISTRIBUTIONS OF AEROSOL RADIATIVE PROPERTIES BASED ON COMBINED AEROSOL OBSERVATIONS FROM CALIPSO AND OTHER A-TRAIN SENSORS | |
| 项目编号 | NNX10AN60G S07 |
| JENS REDEMANN | |
| 项目主持机构 | BAER INSTITUTE |
| 开始日期 | 2010-07-12 |
| 结束日期 | 2014-07-11 |
| 英文摘要 | The inhalation of pharmaceutical nanoparticles may offer many unique advantages compared to conventional delivery methods for the treatment of respiratory diseases, systemic conditions and to unlock the potential use of the lungs to deliver vaccines and gene therapy. However, the current methods used to administer these next-generation nanoparticle pharmaceuticals to the lungs are often inefficient, which can significantly reduce drug effectiveness, increase unwanted side effects, and make dosing difficult to control. The overall goal of this project is to develop a novel technology for the efficient delivery of inhaled nanoparticles that minimizes deposition in the mouth and throat while maximizing deposition in the lungs. |
| 英文关键词 | Address;Adverse effects;aerosolized;Aerosols;Affect;Albuterol Sulfate;Alveolar;Alveolar sac;Animals;Area;Artificial nanoparticles;base;Benchmarking;Benign;Blood capillaries;Blood Circulation;Breathing;Budesonide;Bypass;Caliber;capillary;Characteristics;Charge;Control Groups;Cystic Fibrosis;Deposition;design;Development;Devices;Disadvantaged;Dose;Drug Delivery Systems;Drug Formulations;Economics;Effectiveness;Electrostatics;Engineering;Ensure;Evaluation;Excipients;Exhalation;Exhibits;Exubera;Future;Gene Delivery;gene therapy;Generations;Generic Drugs;Goals;Growth;Guidelines;Human;Humidity;improved;In Vitro;in vitro testing;in vivo;Inhalation Therapy;Inhalators;insight;Insulin;iterative design;Joints;Lung;Lung diseases;Malignant neoplasm of lung;Medicine;Methods;Modality;Modeling;Modification;Morphology;nanoparticle;nanosized;new technology;next generation;Oral;Oral cavity;Outcome;particle;Particle Size;Peptides;Performance;performance tests;Pharmaceutical Preparations;Pharmacologic Substance;Pharyngeal structure;Physical condensation;Powder dose form;Process;Property;public health relevance;Relative (related person);Research Activity;research study;respiratory;Respiratory System;Respiratory Tract Infections;Respiratory tract structure;Route;simulation;Site;small molecule;Sodium Chloride;solid state;Solutions;sugar;Surface;System;Systemic disease;Systemic infection;Techniques;Technology;Testing;Tracheobronchial;Upper respiratory tract;Vaccines;wasting;Water;water vapor;Weight;Wettability;Xylitol |
| 学科分类 | 11 - 工程与技术;1107 - 航空航天工程;03 - 天文学 |
| 资助机构 | US-NASA |
| 国家 | US |
| 语种 | 英语 |
| 文献类型 | 项目 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/76046 |
| 推荐引用方式 GB/T 7714 | JENS REDEMANN.CHARACTERIZING AEROSOL DIRECT RADIATIVE EFFECTS IN CLEAR SKIES AND ABOVE CLOUDS, AND NEAR-CLOUD SPATIAL DISTRIBUTIONS OF AEROSOL RADIATIVE PROPERTIES BASED ON COMBINED AEROSOL OBSERVATIONS FROM CALIPSO AND OTHER A-TRAIN SENSORS.2010. |
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