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| MODELING AND FORECASTING THE IMPACT OF THE LOWER ATMOSPHERE ON THE THERMOSPHERE IONOSPHERE SYSTEM | |
| 项目编号 | NNX11AO61G S01 |
| TIM FULLER-ROWELL | |
| 项目主持机构 | UNIVERSITY OF COLORADO, BOULDER |
| 开始日期 | 2011-08-02 |
| 结束日期 | 2014-08-01 |
| 英文摘要 | The proposed project will develop and demonstrate a miniaturized, portable aerosol sampler that will collect a series of time- and location-resolved personal exposure samples for conducting research into the relationships among environmental exposure, genetics and health. It will also develop a bench-top assay unit that will perform colorimetric assays for endotoxin on the collected samples. The sampler will employ an array of novel micro-channel collectors, and, when combined with a position-monitor (GPS) and activity monitor (accelerometer), will collect a time-series of exposure samples that will be time- and location- stamped to allow researchers to fully characterize the exposure history of subjects as they travel through their environment. The sampling unit will be extremely small, light-weight and battery operated to allow it to be carried in a back-pack even by a 10-year old child. This device will significantly improve the ability to localize exposure events in space and time and will provide a critical tool for use in resolving uncertainties about the relationships between exposure and human health impacts. Each sampling unit will contain a carousel holding an array of micro-channel collectors which will collect samples at 30 minute (or shorter) intervals. The carousel will hold up to 48 collectors allowing samples to be collected over a 24 hour period. Once all the samples have been collected, the carousel will be transferred to the bench-top assay unit which will perform assays on all of the collected samples, greatly reducing the workload associated with the analysis of the numerous samples collected during a typical epidemiological study. This aerosol sampling and detection apparatus will be integrated with automation technology developed by the Pacific Northwest National Laboratory (PNNL) to produce a self-contained portable personal exposure sampling unit and a bench-top assay unit. Enertechnix will be responsible for the aerosol sampling and microfluidic components and for system integration. PNNL will adapt its automation, power management, and position- and motion- sensing technologies for use in the PEM. The University of Washington (UW) will assist in the implementation of an endotoxin assay employing a miniature colorimetric readout unit developed by FAR Sciences. Prototypes will be developed and, in collaboration with the UW, will be field tested in a variety of environments to demonstrate the performance of the sampler and bench-top assay unit. This system will be the first to provide a highly efficient aerosol to microfluidics interface and the first to provide automated, time- and space-resolved sampling in a portable package. |
| 英文关键词 | 10 year old;aerosolized;Aerosols;Affect;Agitation;airway hyperresponsiveness;airway inflammation;Aliquot;Asthma;Automation;Awareness;Back;Biological Assay;Bronchoconstriction;Cardiovascular Diseases;Cells;Cessation of life;Child;Cohort Studies;Collaborations;Collection;cost;design;Detection;Development;Devices;Disease;Elements;Endotoxins;Environment;Environmental Exposure;Environmental Pollution;Environmental Risk Factor;Epidemiologic Studies;Escherichia coli;Event;Excision;exposed human population;Exposure to;Genetic;Gram-Negative Bacteria;Health;Hour;Human;improved;Incidence;Individual;Injection of therapeutic agent;Laboratories;light (weight);Liquid substance;Location;Measurement;Microfluidics;miniaturize;Molds;Monitor;Motion;novel;operation;Pacific Northwest;particle;Particulate;Particulate Matter;Performance;Persons;Phase;Population;Positioning Attribute;Procedures;prototype;Recording of previous events;Research;Research Personnel;Sampling;Science;Series;Severity of illness;Suggestion;Symptoms;System;Systems Integration;Technology;Testing;Time;tool;Travel;Ultrasonics;Uncertainty;United States;Universities;usability;Washington;Work;Workload |
| 学科分类 | 11 - 工程与技术;1107 - 航空航天工程;03 - 天文学 |
| 资助机构 | US-NASA |
| 国家 | US |
| 语种 | 英语 |
| 文献类型 | 项目 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/75583 |
| 推荐引用方式 GB/T 7714 | TIM FULLER-ROWELL.MODELING AND FORECASTING THE IMPACT OF THE LOWER ATMOSPHERE ON THE THERMOSPHERE IONOSPHERE SYSTEM.2011. |
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