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| The Tohoku-Oki earthquake from Earth to Oceans and Space: a critical case-study for earthquake and tsunami anticipation | |
| 项目编号 | ANR-11-JAPN-0008 |
| Monsieur Anthony Sladen | |
| 项目主持机构 | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - DELEGATION REGIONALE COTE D'AZUR |
| 开始日期 | 2011-10-01 |
| 结束日期 | 2013-4-01 |
| 英文摘要 | Severe shortness of breath is a disabling symptom afflicting millions of ageing Americans with heart and lung disease, cancer, and other diseases, and is a common source of suffering near the end of life. The best treatment available, morphine, has serious side effects such as impairment of consciousness and dangerous suppression of breathing. The drug furosemide (used safely for other conditions) has shown promise of relieving dyspnea without these side effects when it is breathed as an aerosol mist, but its effect on shortness of breath has been inconsistent. We will study improved methods of furosemide delivery and dose that we believe will provide much more consistent treatment effectiveness. If this treatment can be made to work consistently, it will have a profound effect on palliative care of patients with severe shortness of breath. |
| 英文关键词 | Adverse effects;aerosolized;Aerosols;Age;Air;American;analog;Area;Back;Breathing;Characteristics;Chronic lung disease;Clinic;Clinical;Clinical effectiveness;clinical practice;Clinical Protocols;Clinical Research;Clinical Sciences;Clinical Trials;Confusion;Conscious;Constipation;cost;Deposition;design;Development;Disadvantaged;Disease;Dose;Drug Delivery Systems;Dyspnea;Effectiveness;effectiveness clinical trial;effectiveness research;end of life;Evaluation;experience;Failure (biologic function);Feedback;Funding;Furosemide;Future;Generations;Grant;Heart Diseases;Human;Hunger;Illusions;Impairment;improved;Individual;Inpatients;Laboratories;Laboratory Finding;Laboratory Study;Lead;Lung;Lung diseases;Malignant Neoplasms;Measurement;Measures;member;Mental Depression;Metered Dose Inhaler Device;Methods;minimal risk;Modeling;Morphine;Nausea;novel;Opiates;Outcome;palliation;Palliative Care;Particle Size;Patients;Pattern;Pharmaceutical Preparations;Physiological;Placebo Control;Procedures;Protocols documentation;Provider;Pulmonary Stretch Receptors;Quality of Care;randomized placebo controlled trial;receptor;Regimen;Research;residence;Respiration;response;Science;Scientist;Sensory;Shortness of Breath;Site;Source;Specificity;Stimulus;symptom management;Symptoms;Testing;Therapeutic Effect;Time;Translating;translational approach;Translational Research;Translations;treatment effect;Treatment Effectiveness;Treatment Efficacy;Treatment Failure;United States National Institutes of Health;Variant;Ventilator;Work |
| 资助机构 | FR-ANR |
| 项目类型 | Great Tohoku Earthquake (FLASH JAPON) 2011 |
| URL | http://www.agence-nationale-recherche.fr/en/anr-funded-project/?solr=run&tx_lwmsuivibilan_pi2%5BCODE%5D=ANR-11-JAPN-0008 |
| 国家 | FR |
| 语种 | 英语 |
| 文献类型 | 项目 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/75486 |
| 推荐引用方式 GB/T 7714 | Monsieur Anthony Sladen.The Tohoku-Oki earthquake from Earth to Oceans and Space: a critical case-study for earthquake and tsunami anticipation.2011. |
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