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| Compensation Between Poleward Energy Transports in the Ocean and Atmosphere | |
| 项目编号 | DE-SC0014433 |
| Kwon, Young-Oh | |
| 项目主持机构 | Woods Hole Oceanographic Institution |
| 开始日期 | 2015-08-01 |
| 结束日期 | 2019-07-31 |
| 英文摘要 | PUBLIC HEALTH RELEVANCE: Delayed lung healing following surgical resection contributes significantly to morbidity and mortality but its pathogenesis remains unknown. This proposal will determine the relationship between increased carbon dioxide concentration and lung healing. We believe that the results from these studies will provide explanation for many clinical associations between conditions leading to hypercarbia and poor outcomes after lung surgery as well as introduce investigative opportunities to study the role of therapies directed towards lowering carbon dioxide or reversing the carbon dioxide-induced alterations in signaling pathways to promote lung repair. |
| 英文关键词 | Cellular biology;chemokine;Clinical;3' Untranslated Regions;abstracting;Academic Training;Address;Air;Alveolar;Alveolar Macrophages;American;Apoptotic;Area;Award;base;Basic Science;Binding (Molecular Function);Biological Assay;Biology;Bone Marrow;Carbon Dioxide;career;cell motility;Cells;Clinical Investigator Award;Clinical Research;Clinical Trials;cofilin;Collaborations;Communities;Complication;Confocal Microscopy;Core Facility;Critical Care;CXCL12 gene;CXCR4 Receptors;Data;Discipline;Environment;Epithelial;Epithelial Cells;Excision;experience;Faculty;Flow Cytometry;Fostering;Foundations;Functional disorder;Funding;Genetic Transcription;Gifts;Grant;Guanine;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate Phosphohydrolases;Healed;healing;Health;Health Care Costs;human subject;Hylobates Genus;Hypercapnia;Immunofluorescence Immunologic;Immunology;Impaired wound healing;improved;in vivo;inhibitor/antagonist;Injury;Institution;Investigation;Knock-out;Knockout Mice;Knowledge;Laboratories;Laboratory Research;Life;LIMK1 gene;Luciferases;Lung;lung repair;Lysosomes;macrophage;Manuscripts;Mediating;Mediator of activation protein;Medicine;meetings;Mentors;MicroRNAs;Microscopy;Microsurgery;migration;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;novel;Operative Surgical Procedures;Outcome;Pathogenesis;Pathway interactions;Patients;Phagocytosis;Phagosomes;Phosphorylation;Physiology;Pleural cavity;Pneumothorax;Positioning Attribute;Postoperative Period;Preparation;Production;prospective;Proteins;Pulmonary Emphysema;reconstitution;repaired;Reporter;Research;research and development;Research Personnel;Research Training;Resolution;Resources;Risk;RNA;Role;Scholarship;Scientist;Signal Pathway;Signal Transduction;Signaling Protein;Site;skills;stem;Surface;Surgeon;Techniques;Thoracic Surgical Procedures;Time;tool;Training;Transfection;Transgenic Organisms;Translational Research;Transplantation;treatment trial;United States;Universities;Washington;Work;wound;Wound Healing |
| 学科分类 | 09 - 环境科学;06 - 生物科学 |
| 资助机构 | US-DOE |
| 项目经费 | 482000 |
| 项目类型 | Grant |
| 国家 | US |
| 语种 | 英语 |
| 文献类型 | 项目 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/74123 |
| 推荐引用方式 GB/T 7714 | Kwon, Young-Oh.Compensation Between Poleward Energy Transports in the Ocean and Atmosphere.2015. |
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