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| PHYTOPLANKTON COMMUNITY STRUCTURE, CARBON STOCK, CARBON EXPORT AND CARBON FLUX: WHAT ROLE DO DIATOMS PLAY IN THE NORTH PACIFIC AND NORTH ATLANTIC OCEANS? | |
| 项目编号 | 80NSSC17K0700 |
| COLLIN ROESLER | |
| 项目主持机构 | BOWDOIN COLLEGE |
| 开始日期 | 2017-09-19 |
| 结束日期 | 2020-09-18 |
| 英文摘要 | Lung cancer is the leading cause of cancer-related deaths worldwide, with non-small cell lung cancer (NSCLC) representing 80%. Despite advances in chemotherapy, the prognosis remains poor, as less than 20% of patients with stage IV disease have even a two-year survival rate. Hence, there is an urgent need for new or repurposed agents that are effective against this disease. Oral bexarotene is used clinically to treat cutaneous T-cell lymphoma, and has shown modest efficacy in clinical trials of NSCLC. Despite its modest efficacy, oral bexarotene causes hypertriglyceridemia and hypercholesterolemia, which limit dose escalation to higher, perhaps more effective doses. We anticipate that aerosol delivery of bexarotene would result in little or no drug being delivered to the blood, thereby reducing/eliminating these systemic adverse effects, while maintaining or increasing its efficacious effects at the target site, the lung. The purpose of this task order is to support the aerosol development of bexarotene. |
| 英文关键词 | Toxic effect;T-Cell Lymphoma;Survival Rate;Site;Recovery;Rattus;Process;Procedures;Pharmaceutical Preparations;Patients;outcome forecast;Oral;Non-Small-Cell Lung Carcinoma;Malignant neoplasm of lung;Lung;Hypertriglyceridemia;hypercholesterolemia;Formulation;Drug Kinetics;Dose;Disease;Development;Cyclic GMP;Cutaneous;clinically relevant;Clinical Trials;Clinical;chemotherapy;Cessation of life;Cancer Etiology;Blood;Bexarotene;base;Animals;Aerosols;Adverse effects |
| 学科分类 | 03 - 天文学;1107 - 航空航天工程;11 - 工程与技术 |
| 资助机构 | US-NASA |
| 国家 | US |
| 语种 | 英语 |
| 文献类型 | 项目 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/73367 |
| 推荐引用方式 GB/T 7714 | COLLIN ROESLER.PHYTOPLANKTON COMMUNITY STRUCTURE, CARBON STOCK, CARBON EXPORT AND CARBON FLUX: WHAT ROLE DO DIATOMS PLAY IN THE NORTH PACIFIC AND NORTH ATLANTIC OCEANS?.2017. |
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