Climate Change Data Portal
| Jets in the Solar Atmosphere | |
| 项目编号 | http://gepris.dfg.de/gepris/projekt/407727365 |
| Professor Dr. MarkusRoth | |
| 项目主持机构 | Leibniz-Institut für Sonnenphysik (KIS) |
| 开始日期 | 2018 |
| 英文摘要 | Absorption, distribution, metabolism and excretion´s studies (ADME) are essential for drug discovery and development, providing invaluable preclinical data to understand how the drug behaves in living organisms, thus allowing to make a decision on whether the drug should be terminated or advanced to the next step. At present, most of these studies are performed with a radiolabelled 14C-labelled version of the drug; unfortunately, current radiolabelling syntheses rely on lengthy-step sequences or rather expensive 14C-labelled building blocks, dramatically raising the costs for the research and development, and delaying the execution of preclinical studies. Taking into consideration that carboxylic acids are privileged motifs in a myriad of agrochemicals or pharmaceuticals, LABEL-DIOX offers the opportunity of promoting a late-stage carboxylation event with labeled CO2. The protocol is user-friendly, with components that are neither air- nor moisture sensitive, utilizes earth-abundant catalysts and operates under mild conditions. LABEL-DIOX will increase the overall efficiency of the carbon isotope incorporation, reduce the costs that would have resulted from the design of a lengthy radiolabelled synthesis, minimize the costs for waste disposal and dramatically increase the revenues, thus changing the way industrial chemists conduct radiolabelling of drugs containing carboxylic acids. |
| 学科分类 | 03 - 天文学 |
| 资助机构 | DE-DFG |
| 项目类型 | Research Grants |
| 国家 | DE |
| 语种 | 英语 |
| 文献类型 | 项目 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/73291 |
| 推荐引用方式 GB/T 7714 | Professor Dr. MarkusRoth.Jets in the Solar Atmosphere.2018. |
| 条目包含的文件 | 条目无相关文件。 | |||||
| 个性服务 |
| 推荐该条目 |
| 保存到收藏夹 |
| 导出为Endnote文件 |
| 谷歌学术 |
| 谷歌学术中相似的文章 |
| [Professor Dr. MarkusRoth]的文章 |
| 百度学术 |
| 百度学术中相似的文章 |
| [Professor Dr. MarkusRoth]的文章 |
| 必应学术 |
| 必应学术中相似的文章 |
| [Professor Dr. MarkusRoth]的文章 |
| 相关权益政策 |
| 暂无数据 |
| 收藏/分享 |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
