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| Long Polar Fimbriae of Attaching and Effacing Escherichia coli | |
| 项目编号 | 5R01AI079154-02 |
| TORRES, ALFREDO G | |
| 项目主持机构 | UNIVERSITY OF TEXAS MEDICAL BR GALVESTON |
| 开始日期 | 2009-04-01 |
| 结束日期 | 2014-3-31 |
| 英文摘要 | Attaching and effacing Escherichia coli (AEEC) represent a diversE group of isolates implicated in diarrhea in humans in several countries. Most AEEC strains possess highly regulated Long Polar (LP) fimbriae, which contribute to the intestinal colonization process of some of the AEEC isolates. Their full characterization will provide new and deeper insights into the process of AEEC colonization, and a better understanding of their regulatory mechanisms controlling expression, which will be a basis for developing novel therapeutics and simplified diagnostic tests |
| 英文关键词 | Adhesions;Animal Model;AT Rich Sequence;Bacterial Adhesins;Bacteriophages;base;Biological Products;Categories;Cells;Collaborations;Country;Data;Diagnostic;Diagnostic tests;Diarrhea;Disease;DNA;Enterocytes;enteropathogenic Escherichia coli;Environment;Escherichia coli;Escherichia coli EHEC;Escherichia coli Infections;Escherichia coli O157;Evolution;Family;fimbria;Fimbrial Adhesins;Food Safety;Funding;Gastrointestinal tract structure;Gene Cluster;Genes;Genetic;genetic regulatory protein;genome sequencing;Goals;Hemolytic-Uremic Syndrome;Human;human disease;improved;In Vitro;in vivo;Infant;Infantile Diarrhea;Infection;Infectious Diseases Research;innovation;insight;Interdisciplinary Study;International;Intestines;Investigation;Knowledge;Lesion;Letters;Link;Mediating;Mobile Genetic Elements;Modeling;novel;novel therapeutics;Organism;Oryctolagus cuniculus;Outcome;pathogen;Pathogenesis;pathogenic bacteria;pathogenic Escherichia coli;Pathogenicity Island;Plasmids;Play;Prevalence Study;prevent;Process;Production;Promoter Regions (Genetics);Property;Proteins;prototype;public health relevance;Regulation;Research;Research Personnel;research study;Resources;Role;Staging;System;Testing;Therapeutic;Therapeutic Uses;tissue tropism;Virulence;Virulence Factors;Virulent;Work |
| 学科分类 | 14 - 医学科学;1426 - 预防医学;1403 - 消化系统;1419 - 医学病原微生物与感染;1418 - 影像医学与生物医学工程 |
| 资助机构 | US-NIH |
| 项目经费 | 375202 |
| 项目类型 | Research Projects |
| 国家 | US |
| 语种 | 英语 |
| 文献类型 | 项目 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/71956 |
| 推荐引用方式 GB/T 7714 | TORRES, ALFREDO G.Long Polar Fimbriae of Attaching and Effacing Escherichia coli.2009. |
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