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| Crosstalk between peroxisomes, endoplasmic reticulum and endosomes during polar growth and development in fungi | |
| 项目编号 | http://gepris.dfg.de/gepris/projekt/351340304 |
| sProfessor Dr. MichaelBölker | |
| 项目主持机构 | Philipps-Universität Marburg |
| 开始日期 | 2017 |
| 英文摘要 | Cellorganelleslikeperoxisomes,theendoplasmicreticulum(ER)andendosomeshavelongbeenconsideredasconfinedcompartmentswithdistinctisolatedfunctions.PeroxisomesparticipateinprimaryandsecondarymetabolismaswellasinReactiveOxygenSpecies(ROS)signaling,whereasendosomesserveasmultipurposeplatformsforlongdistancetransportofmacromolecules.However,recentadvancesshowthatorganellesareratherdynamicstructuresthatheavilyinteractwitheachother.Forexample,aclosemolecularlinkbetweenperoxisomesandendosomeswasestablishedinfungalcellsbyshowingthatmicrotubule-dependenttransportofearlyendosomesdistributesperoxisomesthroughouthyphae.Inaddition,lipiddroplets(LDs)andERsegmentsaretransportedbytheseendosomes.Atthesametime,theformationanddynamicsofLDs,endosomes,andperoxisomesdependontheER.Remarkably,mRNAsencodingseptinsareanadditionalimportantcargoforearlyendosomes.ExperimentaldatasupportamodelinwhichlocaltranslationofseptinmRNAsatthecytoplasmicsurfaceofendosomespromotesseptinoligomerassemblyandformationofhigher-orderstructures.Here,weproposetoinvestigate(i)thebiologicalfunctionofperoxisomesduringpolargrowthanddevelopment,(ii)apotentialfunctionallinkbetweenmRNAtransportandthecrosstalkofperoxisomes,ERandendosomes.ToprovideabroadviewontheseaspectsourteamconsistsoffungalbiologyexpertsusingestablishedmodelsystemssuchasUstilagomaydis,Aspergillusnidulans,NeurosporacrassaandPodosporaanserina.Genetic,biochemicalandcellbiologicalapproacheswillbecombinedtoidentifymolecularmechanismsandessentialcomponentsinorganelledynamics.Bycomparingthecrosstalkbetweenorganellesindifferentfungalmodels,wewilluncoverfundamental,evolutionaryconservedprocesses,aswellasspecificmechanismsadaptedtothelifestylesofdifferentfungi.Obtainedresultswillbeofgeneralinterestforcellbiologistsandthegainedknowledgecanbeappliedtoimprovetheproductionofsecondarymetabolitesandtodevelopnovelfungicides. |
| 学科分类 | 0605 - 生物物理、生物化学与分子生物学;06 - 生物科学 |
| 资助机构 | DE-DFG |
| 项目类型 | Research Grants |
| URL | http://gepris.dfg.de/gepris/projekt/351340304?language=en |
| 国家 | DE |
| 语种 | 英语 |
| 文献类型 | 项目 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/69553 |
| 推荐引用方式 GB/T 7714 | sProfessor Dr. MichaelBölker.Crosstalk between peroxisomes, endoplasmic reticulum and endosomes during polar growth and development in fungi.2017. |
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