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DOI | 10.1007/s00204-016-1817-5 |
Breath biomarkers in toxicology | |
Pleil, Joachim D. | |
发表日期 | 2016-11-01 |
ISSN | 0340-5761 |
卷号 | 90期号:11页码:2669-2682 |
英文摘要 | Exhaled breath has joined blood and urine as a valuable resource for sampling and analyzing biomarkers in human media for assessing exposure, uptake metabolism, and elimination of toxic chemicals. This article focuses current use of exhaled gas, aerosols, and vapor in human breath, the methods for collection, and ultimately the use of the resulting data. Some advantages of breath are the noninvasive and self-administered nature of collection, the essentially inexhaustible supply, and that breath sampling does not produce potentially infectious waste such as needles, wipes, bandages, and glassware. In contrast to blood and urine, breath samples can be collected on demand in rapid succession and so allow toxicokinetic observations of uptake and elimination in any time frame. Furthermore, new technologies now allow capturing condensed breath vapor directly, or just the aerosol fraction alone, to gain access to inorganic species, lung pH, proteins and protein fragments, cellular DNA, and whole microorganisms from the pulmonary microbiome. Future applications are discussed, especially the use of isotopically labeled probes, non-targeted (discovery) analysis, cellular level toxicity testing, and ultimately assessing "crowd breath" of groups of people and the relation to dose of airborne and other environmental chemicals at the population level. |
英文关键词 | Human exposome;Exhaled breath;Breath condensate;Cellular respiration;Mass spectrometry;Adverse outcome pathway |
语种 | 英语 |
WOS记录号 | WOS:000386380700007 |
来源期刊 | ARCHIVES OF TOXICOLOGY |
来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/62343 |
作者单位 | US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA |
推荐引用方式 GB/T 7714 | Pleil, Joachim D.. Breath biomarkers in toxicology[J]. 美国环保署,2016,90(11):2669-2682. |
APA | Pleil, Joachim D..(2016).Breath biomarkers in toxicology.ARCHIVES OF TOXICOLOGY,90(11),2669-2682. |
MLA | Pleil, Joachim D.."Breath biomarkers in toxicology".ARCHIVES OF TOXICOLOGY 90.11(2016):2669-2682. |
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