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DOI10.1093/humrep/dew361
Is human fecundity changing? A discussion of research and data gaps precluding us from having an answer
Smarr, Melissa M.1; Sapra, Katherine J.1; Gemmill, Alison2; Kahn, Linda G.3; Wise, Lauren A.4; Lynch, Courtney D.5; Factor-Litvak, Pam; Mumford, Sunni L.6; Skakkebaek, Niels E.7,8; Slama, Remy9; Lobdell, Danelle T.10; Stanford, Joseph B.11; Jensen, Tina Kold7,8; Boyle, Elizabeth Heger12; Eisenberg, Michael L.13; Turek, Paul J.14; Sundaram, Rajeshwari15; Thoma, Marie E.16; Louis, Germaine M. Buck1
发表日期2017-03-01
ISSN0268-1161
卷号32期号:3页码:499-504
英文摘要

Fecundity, the biologic capacity to reproduce, is essential for the health of individuals and is, therefore, fundamental for understanding human health at the population level. Given the absence of a population (bio) marker, fecundity is assessed indirectly by various individual-based (e. g. semen quality, ovulation) or couple-based e. g. time-to-pregnancy) endpoints. Population monitoring of fecundity is challenging, and often defaults to relying on rates of births fertility) or adverse outcomes such as genitourinary malformations and reproductive site cancers. In light of reported declines in semen quality and fertility rates in some global regions among other changes, the question as to whether human fecundity is changing needs investigation. We review existing data and novel methodological approaches aimed at answering this question from a transdisciplinary perspective. The existing literature is insufficient for answering this question; we provide an overview of currently available resources and novel methods suitable for delineating temporal patterns in human fecundity in future research.


英文关键词epidemiology;fecundity;fertility;gynecologic diseases;time-to-pregnancy;urologic diseases
语种英语
WOS记录号WOS:000398060700004
来源期刊HUMAN REPRODUCTION
来源机构美国环保署
文献类型期刊论文
条目标识符http://gcip.llas.ac.cn/handle/2XKMVOVA/61996
作者单位1.Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Div Intramural Populat Hlth Res, 6710B Rockledge Dr Room 3131A, Bethesda, MD 20829 USA;
2.Univ Calif Berkeley, Dept Demog, Berkeley, CA 94720 USA;
3.Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA;
4.Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02118 USA;
5.Ohio State Univ, Coll Med, Dept Obstet & Gynaecol, Columbus, OH 43212 USA;
6.Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Div Intramural Populat Hlth Res, Epidemiol Branch, Bethesda, MD 20829 USA;
7.Univ Copenhagen, Rigshosp, Dept Growth & Reprod, DK-2100 Copenhagen, Denmark;
8.Univ Copenhagen, Rigshosp, EDMaRC, DK-2100 Copenhagen, Denmark;
9.Univ Grenoble Alpes, CNRS, INSERM, IAB Joint Res Ctr,Team Environm Epidemiol, F-38000 Grenoble, France;
10.US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, Res Triangle Pk, NC 27709 USA;
11.Univ Utah, Dept Family & Prevent Med, Salt Lake City, UT 84108 USA;
12.Univ Minnesota, Dept Sociol & Coll Law, Minneapolis, MN 55455 USA;
13.Stanford Univ, Sch Med, Dept Urol, Stanford, CA 94305 USA;
14.Turek Clin, Beverly Hills, CA 90210 USA;
15.Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Div Intramural Populat Hlth Res, Biostat & Bioinformat Branch, Bethesda, MD 20829 USA;
16.Univ Maryland, Sch Publ Hlth, Dept Family Sci, College Pk, MD 20742 USA
推荐引用方式
GB/T 7714
Smarr, Melissa M.,Sapra, Katherine J.,Gemmill, Alison,et al. Is human fecundity changing? A discussion of research and data gaps precluding us from having an answer[J]. 美国环保署,2017,32(3):499-504.
APA Smarr, Melissa M..,Sapra, Katherine J..,Gemmill, Alison.,Kahn, Linda G..,Wise, Lauren A..,...&Louis, Germaine M. Buck.(2017).Is human fecundity changing? A discussion of research and data gaps precluding us from having an answer.HUMAN REPRODUCTION,32(3),499-504.
MLA Smarr, Melissa M.,et al."Is human fecundity changing? A discussion of research and data gaps precluding us from having an answer".HUMAN REPRODUCTION 32.3(2017):499-504.
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