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DOI | 10.1002/etc.4125 |
Adverse outcome pathway networks I: Development and applications | |
Knapen, Dries1; Angrish, Michelle M.2; Fortin, Marie C.3; Katsiadaki, Ioanna4; Leonard, Marc5; Margiotta-Casaluci, Luigi6; Munn, Sharon7; O'; Brien, Jason M.8; Pollesch, Nathan9; Smith, L. Cody10; Zhang, Xiaowei11; Villeneuve, Daniel L.9 | |
发表日期 | 2018-06-01 |
ISSN | 0730-7268 |
卷号 | 37期号:6页码:1723-1733 |
英文摘要 | Based on the results of a Horizon Scanning exercise sponsored by the Society of Environmental Toxicology and Chemistry that focused on advancing the adverse outcome pathway (AOP) framework, the development of guidance related to AOP network development was identified as a critical need. This not only included questions focusing directly on AOP networks, but also on related topics such as mixture toxicity assessment and the implementation of feedback loops within the AOP framework. A set of two articles has been developed to begin exploring these concepts. In the present article (part I), we consider the derivation of AOP networks in the context of how it differs from the development of individual AOPs. We then propose the use of filters and layers to tailor AOP networks to suit the needs of a given research question or application. We briefly introduce a number of analytical approaches that may be used to characterize the structure of AOP networks. These analytical concepts are further described in a dedicated, complementary article (part II). Finally, we present a number of case studies that illustrate concepts underlying the development, analysis, and application of AOP networks. The concepts described in the present article and in its companion article (which focuses on AOP network analytics) are intended to serve as a starting point for further development of the AOP network concept, and also to catalyze AOP network development and application by the different stakeholder communities. Environ Toxicol Chem 2018;37:1723-1733. (c) 2018 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals, Inc. on behalf of SETAC. |
英文关键词 | Adverse outcome pathway;Risk assessment;Predictive toxicology;Adverse outcome pathway network;Network development;Network topology |
语种 | 英语 |
WOS记录号 | WOS:000434099400020 |
来源期刊 | ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY |
来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/61853 |
作者单位 | 1.Univ Antwerp, Vet Physiol & Biochem, Zebrafishlab, Antwerp, Belgium; 2.US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA; 3.Rutgers State Univ, Ernest Mario Sch Pharm, Dept Pharmacol & Toxicol, Piscataway, NJ USA; 4.Ctr Environm Fisheries & Aquaculture Sci, Weymouth, England; 5.LOreal Adv Res, Aulnay Sous Bois, France; 6.Brunel Univ, Inst Environm Hlth & Soc, London, England; 7.European Commiss, Joint Res Ctr, Ispra, Italy; 8.Environm & Climate Change Canada, Natl Wildlife Res Ctr, Ottawa, ON, Canada; 9.US EPA, Midcontinent Ecol Div, Duluth, MN USA; 10.Univ Florida, Ctr Environm & Human Toxicol, Gainesville, FL USA; 11.Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing, Jiangsu, Peoples R China |
推荐引用方式 GB/T 7714 | Knapen, Dries,Angrish, Michelle M.,Fortin, Marie C.,et al. Adverse outcome pathway networks I: Development and applications[J]. 美国环保署,2018,37(6):1723-1733. |
APA | Knapen, Dries.,Angrish, Michelle M..,Fortin, Marie C..,Katsiadaki, Ioanna.,Leonard, Marc.,...&Villeneuve, Daniel L..(2018).Adverse outcome pathway networks I: Development and applications.ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY,37(6),1723-1733. |
MLA | Knapen, Dries,et al."Adverse outcome pathway networks I: Development and applications".ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 37.6(2018):1723-1733. |
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