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DOI10.1093/aje/kwx139
Maternal Exposure to Nitrogen Dioxide, Intake of Methyl Nutrients, and Congenital Heart Defects in Offspring
Stingone, Jeanette A.1; Luben, Thomas J.2; Carmichael, Suzan L.3; Aylsworth, Arthur S.4,5; Botto, Lorenzo D.6; Correa, Adolfo7,8; Gilboa, Suzanne M.9; Langlois, Peter H.10; Nembhard, Wendy N.11; Richmond-Bryant, Jennifer2; Shaw, Gary M.3; Olshan, Andrew F.12
发表日期2017-09-15
ISSN0002-9262
卷号186期号:6页码:719-729
英文摘要

Nutrients that regulate methylation processes may modify susceptibility to the effects of air pollutants. Data from the National Birth Defects Prevention Study (United States, 1997-2006) were used to estimate associations between maternal exposure to nitrogen dioxide (NO2), dietary intake of methyl nutrients, and the odds of congenital heart defects in offspring. NO2 concentrations, a marker of traffic-related air pollution, averaged across postconception weeks 2-8, were assigned to 6,160 nondiabetic mothers of cases and controls using inverse distance-squared weighting of air monitors within 50 km of maternal residences. Intakes of choline, folate, methionine, and vitamins B-6 and B-12 were assessed using a food frequency questionnaire. Hierarchical regression models, which accounted for similarities across defects, were constructed, and relative excess risks due to interaction were calculated. Relative to women with the lowest NO2 exposure and high methionine intake, women with the highest NO2 exposure and lowest methionine intake had the greatest odds of offspring with a perimembranous ventricular septal defect (odds ratio = 3.23, 95% confidence interval: 1.74, 6.01; relative excess risk due to interaction = 2.15, 95% confidence interval: 0.39, 3.92). Considerable departure from additivity was not observed for other defects. These results provide modest evidence of interaction between nutrition and NO2 exposure during pregnancy.


英文关键词air pollution;birth defects;cardiovascular malformation;methionine;methyl donor;prenatal nutrition;ventricular septal defect
语种英语
WOS记录号WOS:000410728500012
来源期刊AMERICAN JOURNAL OF EPIDEMIOLOGY
来源机构美国环保署
文献类型期刊论文
条目标识符http://gcip.llas.ac.cn/handle/2XKMVOVA/61846
作者单位1.Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA;
2.US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA;
3.Stanford Univ, Dept Pediat, Sch Med, Div Neonatal & Dev Med, Stanford, CA 94305 USA;
4.Univ N Carolina, Sch Med, Dept Pediat, Chapel Hill, NC USA;
5.Univ N Carolina, Sch Med, Dept Genet, Chapel Hill, NC USA;
6.Univ Utah, Dept Pediat, Div Med Genet, Salt Lake City, UT USA;
7.Univ Mississippi, Med Ctr, Dept Med, Jackson, MS 39216 USA;
8.Univ Mississippi, Med Ctr, Dept Pediat, Div Med Genet, Jackson, MS 39216 USA;
9.Ctr Dis Control & Prevent, Div Congenital & Dev Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA;
10.Texas Dept State Hlth Serv, Birth Defects Epidemiol & Surveillance Branch, Austin, TX USA;
11.Univ Arkansas Med Sci, Coll Med, Dept Pediat, Arkansas Ctr Birth Defects Res & Prevent, Little Rock, AR 72205 USA;
12.Univ North Carolina Chapel Hill, Dept Epidemiol, Chapel Hill, NC USA
推荐引用方式
GB/T 7714
Stingone, Jeanette A.,Luben, Thomas J.,Carmichael, Suzan L.,et al. Maternal Exposure to Nitrogen Dioxide, Intake of Methyl Nutrients, and Congenital Heart Defects in Offspring[J]. 美国环保署,2017,186(6):719-729.
APA Stingone, Jeanette A..,Luben, Thomas J..,Carmichael, Suzan L..,Aylsworth, Arthur S..,Botto, Lorenzo D..,...&Olshan, Andrew F..(2017).Maternal Exposure to Nitrogen Dioxide, Intake of Methyl Nutrients, and Congenital Heart Defects in Offspring.AMERICAN JOURNAL OF EPIDEMIOLOGY,186(6),719-729.
MLA Stingone, Jeanette A.,et al."Maternal Exposure to Nitrogen Dioxide, Intake of Methyl Nutrients, and Congenital Heart Defects in Offspring".AMERICAN JOURNAL OF EPIDEMIOLOGY 186.6(2017):719-729.
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