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DOI | 10.3109/10408444.2014.931923 |
A 21st century roadmap for human health risk assessment | |
Pastoor, Timothy P.1; Bachman, Ammie N.2; Bell, David R.3; Cohen, Samuel M.4; Dellarco, Michael5; Dewhurst, Ian C.6; Doe, John E.7; Doerrer, Nancy G.8; Embry, Michelle R.8; Hines, Ronald N.9; Moretto, Angelo10; Phillips, Richard D.2; Rowlands, J. Craig11; Tanir, Jennifer Y.8; Wolf, Douglas C.9; Boobis, Alan R.12 | |
发表日期 | 2014-08-01 |
ISSN | 1040-8444 |
卷号 | 44页码:1-5 |
英文摘要 | The Health and Environmental Sciences Institute (HESI)-coordinated Risk Assessment in the 21st Century (RISK21) project was initiated to develop a scientific, transparent, and efficient approach to the evolving world of human health risk assessment, and involved over 120 participants from 12 countries, 15 government institutions, 20 universities, 2 non-governmental organizations, and 12 corporations. This paper provides a brief overview of the tiered RISK21 framework called the roadmap and risk visualization matrix, and articulates the core principles derived by RISK21 participants that guided its development. Subsequent papers describe the roadmap and matrix in greater detail. RISK21 principles include focusing on problem formulation, utilizing existing information, starting with exposure assessment (rather than toxicity), and using a tiered process for data development. Bringing estimates of exposure and toxicity together on a two-dimensional matrix provides a clear rendition of human safety and risk. The value of the roadmap is its capacity to chronicle the stepwise acquisition of scientific information and display it in a clear and concise fashion. Furthermore, the tiered approach and transparent display of information will contribute to greater efficiencies by calling for data only as needed (enough precision to make a decision), thus conserving animals and other resources. |
英文关键词 | exposure;framework;hazard;problem formulation;risk;risk assessment;risk policy;tiered |
语种 | 英语 |
WOS记录号 | WOS:000340360200001 |
来源期刊 | CRITICAL REVIEWS IN TOXICOLOGY
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来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/61839 |
作者单位 | 1.Syngenta Ltd, Greensboro, NC USA; 2.ExxonMobil Biomed Sci Inc, Annandale, NJ USA; 3.European Chem Agcy, Helsinki, Finland; 4.Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE USA; 5.Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD USA; 6.UK Chem Regulat Directorate, York, N Yorkshire, England; 7.Parker Doe Partnership LLP, Frodsham, Cheshire, England; 8.ILSI Hlth & Environm Sci Inst, Washington, DC 20005 USA; 9.US EPA, ORD, NHEERL, Res Triangle Pk, NC 27711 USA; 10.Univ Milan, Dept Biomed & Clin Sci, Milan, Italy; 11.Dow Chem Co USA, Midland, MI 48674 USA; 12.Univ London Imperial Coll Sci Technol & Med, London, England |
推荐引用方式 GB/T 7714 | Pastoor, Timothy P.,Bachman, Ammie N.,Bell, David R.,et al. A 21st century roadmap for human health risk assessment[J]. 美国环保署,2014,44:1-5. |
APA | Pastoor, Timothy P..,Bachman, Ammie N..,Bell, David R..,Cohen, Samuel M..,Dellarco, Michael.,...&Boobis, Alan R..(2014).A 21st century roadmap for human health risk assessment.CRITICAL REVIEWS IN TOXICOLOGY,44,1-5. |
MLA | Pastoor, Timothy P.,et al."A 21st century roadmap for human health risk assessment".CRITICAL REVIEWS IN TOXICOLOGY 44(2014):1-5. |
条目包含的文件 | 条目无相关文件。 |
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