Climate Change Data Portal
DOI | 10.1016/j.yrtph.2014.09.009 |
Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA) | |
Tollefsen, Knut Erik1; Scholz, Stefan2; Cronin, Mark T.3; Edwards, Stephen W.4; de Knecht, Joop5; Crofton, Kevin4; Garcia-Reyero, Natalia6; Hartung, Thomas7; Worth, Andrew8; Patlewicz, Grace9 | |
发表日期 | 2014-12-01 |
ISSN | 0273-2300 |
卷号 | 70期号:3页码:629-640 |
英文摘要 | Chemical regulation is challenged by the large number of chemicals requiring assessment for potential human health and environmental impacts. Current approaches are too resource intensive in terms of time, money and animal use to evaluate all chemicals under development or already on the market. The need for timely and robust decision making demands that regulatory toxicity testing becomes more cost-effective and efficient. One way to realize this goal is by being more strategic in directing testing resources; focusing on chemicals of highest concern, limiting testing to the most probable hazards, or targeting the most vulnerable species. Hypothesis driven Integrated Approaches to Testing and Assessment (IATA) have been proposed as practical solutions to such strategic testing. In parallel, the development of the Adverse Outcome Pathway (AOP) framework, which provides information on the causal links between a molecular initiating event (MIE), intermediate key events (KEs) and an adverse outcome (AO) of regulatory concern, offers the biological context to facilitate development of IATA for regulatory decision making. This manuscript summarizes discussions at the Workshop entitled "Advancing AOPs for Integrated Toxicology and Regulatory Applications" with particular focus on the role AOPs play in informing the development of IATA for different regulatory purposes. (C) 2014 Elsevier Inc. All rights reserved. |
英文关键词 | Adverse Outcome Pathway (AOP);Integrated Approaches to Testing and Assessment (IATA);(Q)SAR;Read-across;High throughput screening (HTS);High content screening (HCS);Cross species extrapolation |
语种 | 英语 |
WOS记录号 | WOS:000345816900007 |
来源期刊 | REGULATORY TOXICOLOGY AND PHARMACOLOGY |
来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/61774 |
作者单位 | 1.Norwegian Inst Water Res NIVA, N-0349 Oslo, Norway; 2.UFZ Helmholtz Ctr Environm Res, Dept Bioanalyt Ecotoxicol, D-04318 Leipzig, Germany; 3.Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Liverpool L3 3AF, Merseyside, England; 4.US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA; 5.Org Econ Cooperat & Dev, Environm Directorate, Environm Hlth & Safety Div, F-75775 Paris 16, France; 6.Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS USA; 7.Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Ctr Alternat Anim Testing, Baltimore, MD 21205 USA; 8.European Commiss, Joint Res Ctr, Inst Hlth & Consumer Protect, Syst Toxicol Unit, Ispra, Varese, Italy; 9.DuPont Haskell Global Ctr Hlth & Environm Sci, Newark, DE 19711 USA |
推荐引用方式 GB/T 7714 | Tollefsen, Knut Erik,Scholz, Stefan,Cronin, Mark T.,et al. Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)[J]. 美国环保署,2014,70(3):629-640. |
APA | Tollefsen, Knut Erik.,Scholz, Stefan.,Cronin, Mark T..,Edwards, Stephen W..,de Knecht, Joop.,...&Patlewicz, Grace.(2014).Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA).REGULATORY TOXICOLOGY AND PHARMACOLOGY,70(3),629-640. |
MLA | Tollefsen, Knut Erik,et al."Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)".REGULATORY TOXICOLOGY AND PHARMACOLOGY 70.3(2014):629-640. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。