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DOI | 10.1186/s40360-015-0020-2 |
Maternal cadmium, iron and zinc levels, DNA methylation and birth weight | |
Vidal, Adriana C.1; Semenova, Viktoriya2,3; Darrah, Thomas4; Vengosh, Avner5; Huang, Zhiqing6; King, Katherine7,11,12; Nye, Monica D.6,8; Fry, Rebecca9; Skaar, David2; Maguire, Rachel2; Murtha, Amy10; Schildkraut, Joellen11,12; Murphy, Susan6; Hoyo, Cathrine2 | |
发表日期 | 2015-07-15 |
ISSN | 2050-6511 |
卷号 | 16 |
英文摘要 | Background: Cadmium (Cd) is a ubiquitous and environmentally persistent toxic metal that has been implicated in neurotoxicity, carcinogenesis and obesity and essential metals including zinc (Zn) and iron (Fe) may alter these outcomes. However mechanisms underlying these relationships remain limited. Methods: We examined whether maternal Cd levels during early pregnancy were associated with offspring DNA methylation at regulatory sequences of genomically imprinted genes and weight at birth, and whether Fe and Zn altered these associations. Cd, Fe and Zn were measured in maternal blood of 319 women <= 12 weeks gestation. Offspring umbilical cord blood leukocyte DNA methylation at regulatory differentially methylated regions (DMRs) of 8 imprinted genes was measured using bisulfite pyrosequencing. Regression models were used to examine the relationships among Cd, Fe, Zn, and DMR methylation and birth weight. Results: Elevated maternal blood Cd levels were associated with lower birth weight (p = 0.03). Higher maternal blood Cd levels were also associated with lower offspring methylation at the PEG3 DMR in females (beta = 0.55, se = 0.17, p = 0.05), and at the MEG3 DMR in males (beta = 0.72, se = 0.3, p = 0.08), however the latter association was not statistically significant. Associations between Cd and PEG3 and PLAGL1 DNA methylation were stronger in infants born to women with low concentrations of Fe (p < 0.05). Conclusions: Our data suggest the association between pre-natal Cd and offspring DNA methylation at regulatory sequences of imprinted genes may be sex- and gene-specific. Essential metals such as Zn may mitigate DNA methylation response to Cd exposure. Larger studies are required. |
英文关键词 | Cadmium;Zinc;Genomic imprinting;Epigenetics;Pediatrics;Obesity |
语种 | 英语 |
WOS记录号 | WOS:000357850600001 |
来源期刊 | BMC PHARMACOLOGY & TOXICOLOGY |
来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/61527 |
作者单位 | 1.Cedars Sinai Med Ctr, Dept Surg, Div Urol, Los Angeles, CA 90048 USA; 2.N Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, Raleigh, NC 27695 USA; 3.E Carolina Univ, Brody Sch Med, Dept Publ Hlth, Greenville, NC 27834 USA; 4.Ohio State Univ, Sch Earth Sci, Div Water Climate & Environm, Columbus, OH 43210 USA; 5.Duke Univ, Nicholas Sch Environm, Durham, NC 27710 USA; 6.Duke Univ, Sch Med, Div Gynecol Oncol, Dept Obstet & Gynecol, Durham, NC 27710 USA; 7.US EPA, Environm Publ Hlth Div, Chapel Hill, NC 27599 USA; 8.Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA; 9.Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA; 10.Duke Univ, Sch Med, Dept Obstet & Gynecol, Div Maternal Fetal Med, Durham, NC 27710 USA; 11.Duke Univ, Sch Med, Dept Community & Family Med, Durham, NC 27710 USA; 12.Duke Univ, Sch Med, Duke Canc Inst, Durham, NC 27710 USA |
推荐引用方式 GB/T 7714 | Vidal, Adriana C.,Semenova, Viktoriya,Darrah, Thomas,et al. Maternal cadmium, iron and zinc levels, DNA methylation and birth weight[J]. 美国环保署,2015,16. |
APA | Vidal, Adriana C..,Semenova, Viktoriya.,Darrah, Thomas.,Vengosh, Avner.,Huang, Zhiqing.,...&Hoyo, Cathrine.(2015).Maternal cadmium, iron and zinc levels, DNA methylation and birth weight.BMC PHARMACOLOGY & TOXICOLOGY,16. |
MLA | Vidal, Adriana C.,et al."Maternal cadmium, iron and zinc levels, DNA methylation and birth weight".BMC PHARMACOLOGY & TOXICOLOGY 16(2015). |
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