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DOI | 10.1016/j.neuro.2017.09.012 |
Environmental exposure to manganese in air: Tremor, motor and cognitive symptom profiles | |
Kornblith, E. S.1; Casey, S. L.2; Lobdell, D. T.3; Colledge, M. A.4; Bowler, R. M.5 | |
发表日期 | 2018 |
ISSN | 0161-813X |
卷号 | 64页码:152-158 |
英文摘要 | Background: Excessive exposure to manganese (Mn) may cause parkinsonian-like motor and tremor symptoms and adverse cognitive effects, including problems with executive functioning (EF), resembling those found in later-stage Parkinson's disease (PD). Studies seeking to differentiate PD patients into subgroups with associated cognitive and functional outcomes using motor and tremor symptoms identified tremor-dominant (TD) and non-tremor dominant (NTD) subtypes. It is unclear whether differing patterns of pathophysiology and symptoms exist in Mn neurotoxicity, as they do in PD. Methods: Residents of East Liverpool (n = 83) and Marietta, OH (n = 99) exposed to chronic (>10 years) environmental Mn through industrial pollution were administered neuropsychological measures and a physician-rated scale of movement-disorder symptoms. Two-step cluster analysis was used to group residents based on tremor symptoms, bradykinesia/rigidity symptoms, gait disturbance, and executive function. Cluster membership was validated using modeled air-Mn exposure and a computerized tremor measure. Results: Elevated tremor and motor symptoms and executive dysfunction were observed, and TD and NTD symptom clusters were identified. Two additional clusters were also identified: Executive Dysfunction and Normal Functioning. The NTD residents, with elevated levels of gait disturbance and other movement disorder symptoms, did not evidence EF impairment, as predicted. Instead, residents with EF impairment formed their own cluster, and were relatively free of movement disorder symptoms. Conclusions: Results resemble reports in the PD literature with TD and NTD clusters identified, but executive dysfunction did not cluster with NTD symptoms. PD and Mn exposure likely have differing pathophysiology and developmental courses, and therefore different symptom patterns, even when similar symptoms are present. Published by Elsevier B.V. |
英文关键词 | Manganese;Executive function;Neurotoxicology;Tremor |
语种 | 英语 |
WOS记录号 | WOS:000424534200019 |
来源期刊 | NEUROTOXICOLOGY |
来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/61011 |
作者单位 | 1.San Francisco VA Med Ctr, 4150 Clement St, San Francisco, CA 94121 USA; 2.Alliant Int Univ, San Francisco, CA USA; 3.US EPA, Res Triangle Pk, NC 27711 USA; 4.Agcy Tox Subst & Dis Registry, Chicago, IL USA; 5.San Francisco State Univ, San Francisco, CA 94132 USA |
推荐引用方式 GB/T 7714 | Kornblith, E. S.,Casey, S. L.,Lobdell, D. T.,et al. Environmental exposure to manganese in air: Tremor, motor and cognitive symptom profiles[J]. 美国环保署,2018,64:152-158. |
APA | Kornblith, E. S.,Casey, S. L.,Lobdell, D. T.,Colledge, M. A.,&Bowler, R. M..(2018).Environmental exposure to manganese in air: Tremor, motor and cognitive symptom profiles.NEUROTOXICOLOGY,64,152-158. |
MLA | Kornblith, E. S.,et al."Environmental exposure to manganese in air: Tremor, motor and cognitive symptom profiles".NEUROTOXICOLOGY 64(2018):152-158. |
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