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DOI | 10.1111/jne.12169 |
Subcortical Band Heterotopia in Rat Offspring Following Maternal Hypothyroxinaemia: Structural and Functional Characteristics | |
Gilbert, M. E.1; Ramos, R. L.2; McCloskey, D. P.3,4; Goodman, J. H.5,6,7 | |
发表日期 | 2014-08-01 |
ISSN | 0953-8194 |
卷号 | 26期号:8页码:528-541 |
英文摘要 | Thyroid hormones (TH) play crucial roles in brain maturation and are important for neuronal migration and neocortical lamination. Subcortical band heterotopia (SBH) represent a class of neuronal migration errors in humans that are often associated with childhood epilepsy. We have previously reported the presence of SBH in a rodent model of low level hypothyroidism induced by maternal exposure to the goitrogen, propylthiouracil (PTU). In the present study, we report the dose-response characteristics of this developmental malformation and the connectivity of heterotopic neurones with other brain regions, as well as their functionality. Pregnant rats were exposed to varying concentrations of PTU through the drinking water (0-10 p. p. m.) beginning on gestational day 6 to produce graded levels of TH insufficiency. Dose-dependent increases in the volume of the SBH present in the corpus callosum were documented in the adult offspring, with a clear presence at concentrations of PTU that resulted in minor (< 15%) reductions in maternal serum thyroxine as measured when pups were weaned. SBH contain neurones, oligo-dendrocytes, astrocytes and microglia. Monoaminergic and cholinergic processes were prevalent and many of the axons were myelinated. Anatomical connectivity of SBH neurones to cortical neurones and the synaptic functionality of these anatomical connections was verified by ex vivo field potential recordings. SBH persisted in adult offspring despite a return to euthyroid status on termination of exposure and these offspring displayed an increased sensitivity to seizures. Features of this model are attractive with respect to the investigation of the molecular mechanisms of cortical development, the effectiveness of therapeutic intervention in hypothyroxinaemia during pregnancy and the impact of the very modest TH imbalance that accompanies exposure to environmental contaminants. |
英文关键词 | hypothyroxinaemia;foetal brain;neuronal migration;thyroid hormone propylthiouracil |
语种 | 英语 |
WOS记录号 | WOS:000339484600006 |
来源期刊 | JOURNAL OF NEUROENDOCRINOLOGY
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来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/60792 |
作者单位 | 1.US EPA, Tox Assessment Div, Neurotoxicol Branch, Res Triangle Pk, NC 27711 USA; 2.New York Inst Technol, Coll Osteopath Med, Dept Biomed Sci, Old Westbury, NY 11568 USA; 3.CUNY Coll Staten Isl, Dept Psychol, Staten Isl, NY USA; 4.CUNY Coll Staten Isl, Program Dev Neurosci, Staten Isl, NY USA; 5.NY State Inst Basic Res Dev Disabil, Dept Dev Neurobiol, Staten Isl, NY USA; 6.Suny Downstate Med Ctr, Dept Physiol & Pharmacol, Brooklyn, NY 11203 USA; 7.Suny Downstate Med Ctr, Dept Neurol, Brooklyn, NY 11203 USA |
推荐引用方式 GB/T 7714 | Gilbert, M. E.,Ramos, R. L.,McCloskey, D. P.,et al. Subcortical Band Heterotopia in Rat Offspring Following Maternal Hypothyroxinaemia: Structural and Functional Characteristics[J]. 美国环保署,2014,26(8):528-541. |
APA | Gilbert, M. E.,Ramos, R. L.,McCloskey, D. P.,&Goodman, J. H..(2014).Subcortical Band Heterotopia in Rat Offspring Following Maternal Hypothyroxinaemia: Structural and Functional Characteristics.JOURNAL OF NEUROENDOCRINOLOGY,26(8),528-541. |
MLA | Gilbert, M. E.,et al."Subcortical Band Heterotopia in Rat Offspring Following Maternal Hypothyroxinaemia: Structural and Functional Characteristics".JOURNAL OF NEUROENDOCRINOLOGY 26.8(2014):528-541. |
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